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Anti-infective compounds from South African plants
Human infections with organisms such as Staphylococcus aureus  and Mycobacterium tuberculosis  once again have become a major problem due to the development of multidrug-resistant strains of these organisms and new antibiotics are urgently needed. Herewith we want to report the isolation, structural elucidation and activity of compounds with antibiotic activity from four South African plants, Hypericum lalandii (compound 1), H. roeperianum (Hypericaceae) (compound 2), Helichrysum excisum (Asteraceae) (compound 3) and Garuleum bipinnatum (Asteraceae) (compound 4).
Acknowledgements: National research Foundation (South Africa) for financial assistance
References: 1. García-Lara, J. et al. (2005) Drug Disc Today 10:643.
2. Leanaerts, A.J. et al. (2008) Trends Microbiol 16:48.