A Facile Synthetic Route towards
Substituted Thieno[3,2-e]indoles

Wim Van Snick; Wienand Nulens; Sarah Jambon; Wim Dehaen

doi:10.1055/s-0028-1083366

PAPER

A Facile Synthetic Route towards Substituted Thieno[3,2-e]indoles

Wim Van Snick, Wienand Nulens, Sarah Jambon, Wim Dehaen*
Department of Chemistry, K. U. Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium
Fax: +32(16)327990; e-Mail: wim.dehaen@chem.kuleuven.be;

Abstract

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Abstract

A number of substituted thieno[3,2-e]indoles have been prepared in high yields via a tetrabutylammonium fluoride mediated cyclization of 5-acetamido-4-ethynylbenzothiophenes, which, in turn, are easily accessible from the corresponding 4-iodobenzothiophenes. This method presents a viable alternative to the traditionally used Fischer indolization procedures.

Key words

thienoindoles - palladium - cyclizations - fused-ring systems - tetrabutylammonium fluoride

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