Horm Metab Res 2008; 40(9): 614-619
DOI: 10.1055/s-0028-1082085

© Georg Thieme Verlag KG Stuttgart · New York

Modulation of Insulin Action by Advanced Glycation Endproducts: A New Player in the Field

C. G. Schalkwijk 1 , O. Brouwers 1 , C. D. A. Stehouwer 1
  • 1Department of Internal Medicine, Division of General Internal Medicine, University Hospital Maastricht, The Netherlands
Further Information

Publication History

received 27.10.2007

accepted 21.02.2008

Publication Date:
15 September 2008 (online)


Insulin resistance is characterized by an impaired responsiveness to the action of insulin at its multiple target organs. The accumulation of advanced glycation endproducts (AGEs) has been demonstrated in clinical settings of insulin resistance such as in diabetes, hypertension, and obesity. In this review we have focused on advanced glycation as a modulator of insulin resistance. Structural and functional abnormalities of the insulin molecule by glycation and methylglyoxal may contribute to the pathogenesis of insulin resistance. In addition, it is likely that AGEs interfere in the complex molecular pathways of insulin signaling and as such in insulin resistance.


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Dr. C. G. Schalkwijk

Department of Internal Medicine

University Hospital Maastricht

Debeyelaan 25

P.O. Box 5800

6202 AZ Maastricht

The Netherlands

Phone: +31/43/388 21 86

Fax: +31/43/387 50 06

Email: C.Schalkwijk@intmed.unimaas.nl