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CC BY 4.0 · TH Open 2025; 09: a27706902
DOI: 10.1055/a-2770-6902
Case Report

Anticoagulant Therapy in Neonatal Acute Infectious Peritonitis Based on the TAT, PIC, t-PAIC, and sTM: A New Case Series

Autor*innen

  • Wenya Wang 

    1   Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China
    2   Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China

  • Yue Gao

    1   Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China
    2   Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China

  • Yan Qiao

    3   Department of Pediatrics, Shanxi Coal Central Hospital, Taiyuan, Shanxi, China

  • Yang Wu

    4   Department of Pediatric Surgery, Sichuan University West China Hospital, Chengdu, Sichuan, China

  • Jiao Li

    1   Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China
    2   Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China

  • Li Zhang 

    1   Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China
    2   Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China

Funding This work was supported by the grants from the Sichuan Provincial Science and Technology Support Program (Grant: 2022YFS0044 to L.Z.).
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Abstract

Neonatal acute peritonitis is a leading cause of morbidity and mortality and poses challenges that demand prompt diagnosis and treatment, particularly in infants with disseminated intravascular coagulation. Here, we report a case series of four infants with acute peritonitis caused by necrotizing enterocolitis, gastrointestinal perforation, and meconium peritonitis. Laboratory tests for thrombin–antithrombin III complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC), soluble thrombomodulin (sTM), and tissue plasminogen activator–inhibitor complex (t-PAIC) suggested the activation of the coagulation system followed by treatment with anticoagulant therapy in these infants. Overall, TAT, PIC, t-PAIC, and sTM may guide anticoagulant therapy, offering prospects for improving the outcomes in neonates with acute peritonitis.

Keywords

LMW-heparin - hypercoagulability - infectious diseases - acute peritonitis - TAT - PIC - sTM - t-PAIC

Data Availability Statement

The datasets are available on request from the corresponding author.


Ethical Approval

This study protocol was reviewed and approved by the West China Second University Hospital of Sichuan University Medical Ethics Committee, approval number 22ZDYF0841.


Informed Consent

Written informed consent was obtained from the legal guardian to participate in this study and for the publication of any potentially identifiable images or data included in this article.




Publikationsverlauf

Eingereicht: 12. September 2025

Angenommen: 11. Dezember 2025

Accepted Manuscript online:
15. Dezember 2025

Artikel online veröffentlicht:
31. Dezember 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Wenya Wang, Yue Gao, Yan Qiao, Yang Wu, Jiao Li, Li Zhang. Anticoagulant Therapy in Neonatal Acute Infectious Peritonitis Based on the TAT, PIC, t-PAIC, and sTM: A New Case Series. TH Open 2025; 09: a27706902.
DOI: 10.1055/a-2770-6902
 

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