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DOI: 10.1055/a-2741-0910
Recent Advances in the Synthesis of Axially Chiral Cycloalkanes
Autoren
This work is supported by the National Natural Science Foundation of China (22301194 and 22371189), the Natural Science Foundation of Sichuan Province (2025ZNSFSC0918), the Sichuan University Postdoctoral Interdisciplinary Innovation Fund, and the ‘Thousand Young Talents Program’ of China (15-YINGXIA).
Abstract
Axially chiral cycloalkanes have recently emerged as compelling scaffolds with broad utility in asymmetric catalysis and molecular design. This graphical review provides a concise overview of synthetic strategies for constructing axially chiral cycloalkanes. Representative methods summarized include asymmetric allylic substitution, alkene insertion, carbene cross-coupling, carbonyl condensation/reduction, [2+2] cycloaddition, and deracemization. We offer fundamental insights into this emerging field, aiming to facilitate future research toward novel chiral frameworks.
Key words
axial chirality - alkylidenes - cyclic alkanes - asymmetric transformations - desymmetrizationPublikationsverlauf
Eingereicht: 23. September 2025
Angenommen nach Revision: 03. November 2025
Accepted Manuscript online:
06. November 2025
Artikel online veröffentlicht:
24. November 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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