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TumorDiagnostik & Therapie 2025; 46(09): 618-624
DOI: 10.1055/a-2718-7936
DOI: 10.1055/a-2718-7936
Thieme Onkologie aktuell
PSMA PET/CT zum Staging und Restaging des Prostatakarzinoms
PSMA PET/CT for staging and restaging of prostate cancerAuthors
Zusammenfassung
Das Prostatakarzinom ist die häufigste Krebserkrankung bei Männern weltweit. Eine
präzise Bildgebung ist entscheidend für das Staging, die Therapieplanung und das Restaging
der Erkrankung, insbesondere bei fortgeschrittenen Stadien oder Rezidiven. Die PSMA
PET hat sich als präzise Methode zur Beurteilung des Tumorstadiums etabliert, indem
sie das Prostata-spezifische Membranantigen (PSMA) als Zielmolekül nutzt, welches
in ca. 85% auf Prostatakarzinomzellen überexprimiert wird. Im Vergleich zu konventionellen
Bildgebungsverfahren wie der Computertomographie (CT), Magnetresonanztomographie (MRT)
und Skelettszintigrafie bietet die PSMA PET/CT eine höhere Sensitivität und Präzision
bei der Detektion von Metastasen.
Die PSMA PET kann bei Vorliegen eines Prostatakarzinoms sowohl für das initiale Staging
im high-risk Stadium als auch in der Situation des biochemischen Rezidivs genutzt
werden, findet aber auch Einsatz im Restaging des fortgeschrittenen, metastasierten
oder progredienten Prostatakarzinoms sowie vor Durchführung der PSMA-gerichteten Radioligandentherapie
zur Evaluation einer ausreichenden PSMA-Expression. Insgesamt stellt die PSMA PET/CT
eine revolutionäre Weiterentwicklung in der Bildgebung und Therapie des Prostatakarzinoms
dar.
Abstract
Prostate cancer is the most common cancer in men worldwide. Accurate imaging is critical
for staging, treatment planning and restaging of the disease, especially in advanced
or recurrent disease. PSMA PET has established itself as an accurate method of staging
prostate cancer using prostate-specific membrane antigen (PSMA) as a target molecule,
which is over-expressed on prostate cancer cells in approximately 85% of cases. Compared
to conventional imaging modalities such as computed tomography (CT), magnetic resonance
imaging (MRI) and skeletal scintigraphy, PSMA PET/CT offers greater sensitivity and
accuracy in detecting metastases.
PSMA PET/CT can be used for initial staging of high-risk prostate cancer and for biochemical
recurrence, as well as for restaging of advanced, metastatic or progressive prostate
cancer and prior to PSMA-directed radioligand therapy for evaluating a sufficient
PSMA expression. Overall, PSMA PET/CT represents a revolutionary advance in the imaging
and treatment of prostate cancer.
Publication History
Article published online:
25 November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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