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DOI: 10.1055/a-2665-0311
A Rare Case of Pulmonary Inflammatory Myofibroblastic Tumor Mimicking Malignancy in a 37-Year-old Woman: Insights from Radiological and Surgical Management
Ein seltener Fall eines pulmonalen entzündlichen myofibroblastischen Tumors mit bösartigen Bild bei einer 37-jährigen Frau: Erkenntnisse aus der radiologischen und chirurgischen Behandlung
Introduction
Inflammatory myofibroblastic tumor (IMT) is a scarce mesenchymal neoplasm that primarily affects young adults and children [1]. While generally benign, IMTs have a tendency for local recurrence and, in rare cases, malignant transformation [2] [3] [4] [5] [6]. Although the exact mechanisms underlying IMT formation remain unknown, factors such as surgical inflammation, trauma, and immunological responses play a significant role in developing this condition. Additionally, nonspecific symptoms and radiological findings during the diagnostic phase can entangle an on-point diagnosis. As a result, clinical and histopathological examinations become crucial in managing the case. Due to their rarity, IMTs are often misdiagnosed, which may result in complex clinical challenges. The importance of the responsibilities of medical professionals is underscored by the fact that accurate diagnosis is paramount. With this in mind, radiological imaging, including Thorax CT and PET/CT, is the gold standard in the diagnostic process while aiding surgical treatment planning.
Publikationsverlauf
Eingereicht: 22. Februar 2025
Angenommen nach Revision: 23. Juli 2025
Artikel online veröffentlicht:
20. August 2025
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References
- 1 Strater A, Huber A, Rudolph J. et al. 4D-Flow MRI: Technique and Applications. Rofo 2018; 190: 1025-1035
- 2 Gleason BC, Hornick JL. Inflammatory myofibroblastic tumours: Where are we now?. J Clin Pathol 2008; 61: 428-437
- 3 Karaoglu AS, Demir MH, Ayaz A. et al. Inflammatory myofibroblastic tumor of the breast: a case report. Intl J Human Health Sci 2020; 4: 305-308
- 4 Libby EK, Ellis LT, Weinstein S. et al. Metastatic inflammatory myofibroblastic tumor of the bladder. Urol Case Rep 2018; 23: 10-12
- 5 Koç N, Cesur S, Ihvan AN. et al. Round ligaman Kaynaklı retroperitoneal inflamatuar myofibroblastik tümör. Şişli Etfal Hastanesi Tıp Bülteni 2016; 50: 330
- 6 Bulut G, Almalı A, Erten R. et al. Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu. J Clin Exp Invest 2015; 6 (03) 315-317
- 7 Warren S, Gates O. Inflammatory pseudotumor of the lung. Am J Pathol 1939; 15: 69-91
- 8 Coffin CM, Watterson J, Priest JR. et al. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 2007; 31: 1467-1479
- 9 Bisogno G. et al. Inflammatory myofibroblastic tumors in children: A retrospective study of 25 cases. Cancer 2002; 94: 252-261
- 10 Moran CA. et al. Inflammatory myofibroblastic tumors of the lung: A clinicopathologic and immunohistochemical study of 50 cases. Hum Pathol 1998; 29: 1444-1448
- 11 Sukov WR. et al. Inflammatory myofibroblastic tumors of the abdomen and retroperitoneum: A clinicopathologic study of 31 cases. Am J Surg Pathol 2007; 31: 101-111
- 12 Meis-Kindblom JM, Kjellström C, Kindblom LG. Inflammatory fibrosarcoma: update, reappraisal, and perspective on its place in the spectrum of inflammatory myofibroblastic tumors. Semin Diagn Pathol 1998; 15 (02) 133-143
- 13 Burt M, Ihde JK, Hajdu SI. et al. Primary sarcomas of the mediastinum: results of therapy. J Thorac Cardiovasc Surg 1998; 115 (03) 671-680
- 14 Moertel CG. Multiple primary malignant neoplasms: historical perspectives. Cancer 1977; 40 (04) 1786-1792
- 15 Shields TW. et al. General features and complications of pulmonary resections. Gen Thorac Surg 2009; 1: 797-802
- 16 Coffin CM, Watterson J, Priest JR. et al. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995; 19: 859-872
- 17 Lovly CM, Gupta A, Lipson D. et al. Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions. Cancer Discov 2014; 4: 889-895
- 18 Butrynski MD, DʼAdamo DR, Hornick JL. et al. Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor. N Engl J Med 2010; 363: 1727-1733
- 19 Mossé YP, Voss SD, Lim MS. et al. Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Childrenʼs Oncology Group Study. J Clin Oncol 2017; 35: 3215-3221
- 20 Perrone T. et al. Inflammatory myofibroblastic tumors: A clinicopathologic study of 50 cases. Am J Clin Pathol 1984; 81: 543-553
- 21 Kim JH. et al. Pulmonary inflammatory pseudotumor (inflammatory myofibroblastic tumor): CT features with pathologic correlation. J Comput Assist Tomogr 2005; 29: 127-131
- 22 Mullen JR. et al. Inflammatory myofibroblastic tumors of the lung: A clinicopathologic and immunohistochemical study of 50 cases. Arch Pathol Lab Med 1995; 119: 927-933