Bronchopulmonale Karzinoide: klinisches Vorgehen bei einer seltenen Tumorentität

Zusammenfassung

Typische und atypische Karzinoide der Lunge sind seltene Tumoren mit einer Inzidenz von etwa 0,5 pro 100000 Einwohner. Ein Drittel der Betroffenen bleibt asymptomatisch. Abhängig von Lokalisation, Größe und Wachstum treten Husten, Hämoptysen und pneumonieartige Symptome im Falle einer Obstruktion auf. Die Behandlung ist üblicherweise interdisziplinär. Therapie der Wahl bei lokal begrenzten Karzinoiden ist eine anatomische Resektion.

Publication History

Article published online:
02 September 2025

• Literatur

• 1 Kaifi JT, Kayser G, Ruf J. et al. The Diagnosis and Treatment of Bronchopulmonary Carcinoid. Dtsch Arztebl Int 2015; 112: 479-485
• 2 Hage R, de la Rivière AB, Seldenrijk CA. et al. Update in pulmonary carcinoid tumors: a review article. Ann Surg Oncol 2003; 10: 697-704
• 3 García-Yuste M, Matilla JM, Cueto A. et al. Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung for the Spanish Society of Pneumonology and Thoracic Surgery (EMETNE-SEPAR). Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung. Eur J Cardiothorac Surg 2007; 31: 192-197
• 4 Jeung MY, Gasser B, Gangi A. et al. Bronchial carcinoid tumors of the thorax: spectrum of radiologic findings. Radiographics 2002; 22: 351-365
• 5 Bertino EM, Confer PD, Colonna JE. et al. Pulmonary neuroendocrine/carcinoid tumors: a review article. Cancer 2009; 115: 4434-4441
• 6 De Giorgi U, Fanini F, Amadori D. et al. Tumorlets in familial history of bronchopulmonary carcinoid. J Thorac Oncol 2011; 6: 1613-1614
• 7 Klöppel G. Oberndorfer and his successors: from carcinoid to neuroendocrine carcinoma. Endocr Pathol 2007; 18: 141-144
• 8 Leivaditis V, Grapatsas K, Ehle B. et al. Modified pericostal suture technique to reduce postoperative pain and provide optimum anatomic restoration after conversion of minimally invasive thoracic surgery to thoracotomy. Kardiochir Torakochirurgia Pol 2023; 20: 193-199
• 9 Halperin DM, Shen C, Dasari A. et al. Frequency of carcinoid syndrome at neuroendocrine tumour diagnosis: a populationbased study. Lancet Oncol 2017; 18: 525-534
• 10 Scanagatta P, Montresor E, Pergher S. et al. Cushing’s syndrome induced by bronchopulmonary carcinoid tumours: a review of 98 cases and our experience of two cases. Chir Ital 2004; 56: 63-70
• 11 Telega A, Kos-Kudła B, Foltyn W. et al. Selected neuroendocrine tumour markers, growth factors and their receptors in typical and atypical bronchopulmonary carcinoids. Endokrynol Pol 2012; 63: 477-482
• 12 Travis WD, Giroux DJ, Chansky K. et al. International Staging Committee and Participating Institutions. The IASLC Lung Cancer Staging Project: proposals for the inclusion of broncho-pulmonary carcinoid tumors in the forthcoming (seventh) edition of the TNM Classification for Lung Cancer. J Thorac Oncol 2008; 3: 1213-1223
• 13 Kayser K, Kayser C, Rahn W. et al. Carcinoid tumors of the lung: immuno- and ligandohistochemistry, analysis of integrated optical density, syntactic structure analysis, clinical data, and prognosis of patients treated surgically. J Surg Oncol 1996; 63: 99-106
• 14 Filosso PL, Rena O, Donati G. et al. Bronchial carcinoid tumors: surgical management and long-term outcome. J Thorac Cardiovasc Surg 2002; 123: 303-309
• 15 Detterbeck FC. Management of carcinoid tumors. Ann Thorac Surg 2010; 89: 998-1005
• 16 Venkitaraman B, Karunanithi S, Kumar A. et al. Role of 68Ga-DOTATOC PET/CT in initial evaluation of patients with suspected bronchopulmonary carcinoid. Eur J Nucl Med Mol Imaging 2014; 41: 856-864
• 17 Lococo F, Treglia G. Which is the best strategy for diagnosing bronchial carcinoid tumours? The role of dual tracer PET/CT scan. Hell J Nucl Med 2014; 17: 7-9
• 18 Papaporfyriou A, Domayer J, Meilinger M. et al. Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature. Eur Respir Rev 2021; 30 200115
• 19 Queiroz RM, Santana DBF, Nastri Filho R. et al. Endobronchial carcinoid tumor: Radiological findings of a clinical case. Rev Assoc Med Bras (1992) 2018; 64: 15-18
• 20 Dalar L, Ozdemir C, Abul Y. et al. Endobronchial Treatment of Carcinoid Tumors of the Lung. Thorac Cardiovasc Surg 2016; 64: 166-171
• 21 Zhang Z, Zhang Y, Feng H. et al. Is video-assisted thoracic surgery lobectomy better than thoracotomy for early-stage nonsmall-cell lung cancer? A systematic review and meta-analysis. Eur J Cardiothorac Surg 2013; 44: 407-414
• 22 Bölükbas S, Schirren J. Parenchyma-sparing bronchial sleeve resections in trauma, benign and malign diseases. Thorac Cardiovasc Surg 2010; 58: 32-37
• 23 Neuberger M, Hapfelmeier A, Schmidt M. et al. Carcinoid tumours of the lung and the ‘PEPPS’ approach: evaluation of preoperative bronchoscopic tumour debulking as preparation for subsequent parenchyma-sparing surgery. BMJ Open Respir Res 2015; 2 e000090
• 24 Limaiem F, Tariq MA, Ismail U. et al. Lung Carcinoid Tumors. StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. Accessed March 30, 2025 at: https://www.ncbi.nlm.nih.gov/books/NBK537080/
• 25 Singh D, Chen Y, Cummings MA. et al. Inoperable Pulmonary Carcinoid Tumors: Local Control Rates With Stereotactic Body Radiotherapy/Hypofractionated RT With Image-Guided Radiotherapy. Clin Lung Cancer 2019; 20: e284-e290
• 26 Yao JC, Oh DY, Qian J. et al. Everolimus for the treatment of advanced gastrointestinal or lung nonfunctional neuroendocrine tumors in East Asian patients: a subgroup analysis of the RADIANT-4 study. Onco Targets Ther 2019; 12: 1717-1728
• 27 Fazio N, Carnaghi C, Buzzoni R. et al. Relationship between metabolic toxicity and efficacy of everolimus in patients with neuroendocrine tumors: A pooled analysis from the randomized, phase 3 RADIANT-3 and RADIANT-4 trials. Cancer 2021; 127: 2674-2682
• 28 Baudin E, Caplin M, Garcia-Carbonero R. et al. ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2021; 32: 439-451