Abstract
Ewing's sarcoma, though rare, primarily affects children and young adults, commonly
manifesting in long bones. Cranial involvement, particularly in the frontal bone,
is exceptionally uncommon, posing diagnostic and therapeutic challenges. Meticulous
pathological assessment is crucial for recognizing and managing such atypical presentations.
A 16-year-old male presented with left frontal swelling and neurological symptoms.
Imaging revealed a space-occupying lesion involving the left frontal bone with intracranial
extension. Histopathology confirmed Ewing's sarcoma based on characteristic findings
and positive immunohistochemical markers. Differential diagnoses include metastatic
neuroblastoma, primitive neuroectodermal tumors, and chordomas, highlighting the importance
of comprehensive evaluation. Ewing's sarcoma involving the skull necessitates a multidisciplinary
approach for accurate diagnosis and management. This case underscores the significance
of clinical, radiological, and pathological assessments in recognizing rare manifestations.
Collaboration among teams is crucial for tailored management strategies and optimal
patient outcomes.
Keywords
Ewing's sarcoma - frontal bone - intracranial - bone tumor
