Subscribe to RSS
DOI: 10.1055/a-2636-4424
Adherence to Prophylactic Use of Homeopathic Arsenicum album during COVID-19 in India: A Cross-Sectional Study in 23 Cities
Authors
Funding Information This study was funded by the Central Council for Research in Homoeopathy, New Delhi, India.

Abstract
Background
The Indian government, in response to the coronavirus disease 2019 (COVID-19) pandemic, initiated campaigns to use complementary therapies for its prevention and control, such as large-scale distribution of the homeopathic medicine, Arsenicum album 30C, as potential prophylactic for COVID-19. This study estimates the individual adherence to using this homeopathic prophylactic within the Indian urban population.
Methods
A multi-center, cross-sectional, study was conducted across 23 cities in 19 Indian states and union territories from September to November 2022. Participants aged 18 years and above, who had received Arsenicum album 30C within the past month, were included. Adherence was assessed through self-reports. Data were collected in a structured data collection form. Factors influencing adherence were analysed using logistic regression.
Results
A total of 23,101 participants completed the survey. Among the participants, 79.89% (n = 18,457) completed the prescribed three-dose regimen, demonstrating high adherence. Older adults (≥61 years) exhibited the highest adherence (84.63%), whereas younger individuals had lower adherence rates. Employment status, gender and socio-economic class were significant predictors of adherence. Participants with a lower perceived risk of COVID-19 showed higher adherence (adjusted odds ratio = 1.86; 95% confidence interval, 1.73 to 1.99; p < 0.0001). Adverse events were reported by 0.1% (n = 22) of participants, with no serious effects observed.
Conclusion
The high adherence to Arsenicum album 30C highlights the effectiveness of a structured government distribution program and the potential of homeopathy as a welcomed medication in aiming to enhance public health.
Publication History
Received: 28 January 2025
Accepted: 14 June 2025
Article published online:
07 October 2025
© 2025. Faculty of Homeopathy. This article is published by Thieme.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
-
References
- 1 Ahuja M. Azadi Ka Amrit Mahotsav – celebrations of 75th independence anniversary of India – healthy aging!. J Midlife Health 2022; 13: 93-95
- 2 Ministry of AYUSH. Advisory from Ministry of AYUSH for meeting the challenge arising out of spread of coronavirus (COVID-19) in India. Accessed June 3, 2025 at: https://www.pib.gov.in/newsite/PrintRelease.aspx?relid=200005#:~:text=The%20holistic%20approach%20of%20AYUSH,on%20presentations%20of%20the%20symptoms
- 3 Ministry of AYUSH. Ayurveda's immunity boosting measures for self-care during COVID 19 crisis. Accessed June 3, 2025 at: https://www.pib.gov.in/PressReleasePage.aspx?PRID=1609524
- 4 Nayak D, Nahar K, Bhalerao R. et al. Effectiveness of Arsenicum album 30C in prevention of COVID-19 in individuals residing in containment zones of Delhi—a prospective, community-based, parallel cohort study. Homeopathy 2022; 111: 261-270
- 5 Nayak D, Devarajan K, Pal PP. et al. Efficacy of Arsenicum album 30C in the prevention of COVID-19 in individuals residing in containment areas: a prospective, multicenter, cluster-randomized, parallel-arm, community-based, open-label study. Complement Med Res 2023; 30: 375-385
- 6 Wilhelmsen NC, Eriksson T. Medication adherence interventions and outcomes: an overview of systematic reviews. Eur J Hosp Pharm 2019; 26: 187-192
- 7 Simon-Tuval T, Triki N, Chodick G, Greenberg D. The association between adherence to cardiovascular medications and healthcare utilization. Eur J Health Econ 2016; 17: 603-610
- 8 Haynes RB, Devereaux PJ, Guyatt GH. Physicians' and patients' choices in evidence based practice. BMJ 2002; 324: 1350
- 9 von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med 2007; 4: e296
- 10 Saleem SM, Jan SS. Modified Kuppuswamy socioeconomic scale updated for the year 2021. Indian J Forensic Community Med 2021; 8: 1-3
- 11 National Center for Complementary and Integrative Health. Forms and Logs (Adverse Event Forms). Accessed June 3, 2025 at: https://www.nccih.nih.gov/grants/toolbox/forms-and-logs
- 12 Haldane V, Chuah FLH, Srivastava A. et al. Community participation in health services development, implementation, and evaluation: a systematic review of empowerment, health, community, and process outcomes. PLoS One 2019; 14: e0216112
- 13 Hovland CI, Weiss W. The influence of source credibility on communication effectiveness. Public Opin Q 1951; 15: 635-650
- 14 Conn VS, Ruppar TM. Medication adherence outcomes of 771 intervention trials: systematic review and meta-analysis. Prev Med 2017; 99: 269-276
- 15 Lam WY, Fresco P. Medication adherence measures: an overview. BioMed Res Int 2015; 2015: 217047
- 16 Jimmy B, Jose J. Patient medication adherence: measures in daily practice. Oman Med J 2011; 26: 155-159
- 17 Bish A, Michie S. Demographic and attitudinal determinants of protective behaviours during a pandemic: a review. Br J Health Psychol 2010; 15: 797-824
- 18 World Health Organization. WHO Regional Office for Europe. Survey tool and guidance: Rapid, simple, flexible behavioural insights on COVID-19,. 2020 . Accessed June 3, 2025 at: https://iris.who.int/handle/10665/333549
- 19 Tripathi R, Alqahtani SS, Albarraq AA. et al. Awareness and preparedness of COVID-19 outbreak among healthcare workers and other residents of south-west Saudi Arabia: a cross-sectional survey. Front Public Health 2020; 8: 482
- 20 Khaled A, Siddiqua A, Makki S. The knowledge and attitude of the community from the Aseer region, Saudi Arabia, toward COVID-19 and their precautionary measures against the disease. Risk Manag Healthc Policy 2020; 13: 1825-1834
- 21 Bertoldi AD, de Barros AJ, Wagner A, Ross-Degnan D, Hallal PC. Medicine access and utilization in a population covered by primary health care in Brazil. Health Policy 2009; 89: 295-302
- 22 Bertoldi AD, Barros AJ, Hallal PC, Lima RC. [Drug utilization in adults: prevalence and individuals determinants]. Rev Saude Publica 2004; 38: 228-238
- 23 Arrais PS, Brito LL, Barreto ML, Coelho HL. [Prevalence and determinants of medicines consumption in Fortaleza, Ceará, Brazil]. Cad Saude Publica 2005; 21: 1737-1746
- 24 Costa KS, Barros MB, Francisco PM, César CL, Goldbaum M, Carandina L. [Use of medication and associated factors: a population-based study in Campinas, São Paulo State, Brazil]. Cad Saude Publica 2011; 27: 649-658
- 25 Sheehan J, Laver K, Bhopti A. et al. Methods and effectiveness of communication between hospital allied health and primary care practitioners: a systematic narrative review. J Multidiscip Healthc 2021; 14: 493-511
