CC BY 4.0 · AJP Rep
DOI: 10.1055/a-2626-9145
Case Report

Thyroid Storm Triggered by Partial Hydatidiform Mole: A Rare and Life-Threatening Complication

Hailey Cox
1   OBGYN, The University of Toledo, Toledo, United States (Ringgold ID: RIN7923)
2   ProMedica Toledo Hospital, Toledo, United States (Ringgold ID: RIN25323)
,
Maggie Wong
1   OBGYN, The University of Toledo, Toledo, United States (Ringgold ID: RIN7923)
2   ProMedica Toledo Hospital, Toledo, United States (Ringgold ID: RIN25323)
,
Jena Preszler
1   OBGYN, The University of Toledo, Toledo, United States (Ringgold ID: RIN7923)
2   ProMedica Toledo Hospital, Toledo, United States (Ringgold ID: RIN25323)
,
Nikolina Docheva
2   ProMedica Toledo Hospital, Toledo, United States (Ringgold ID: RIN25323)
,
Nauman Khurshid
2   ProMedica Toledo Hospital, Toledo, United States (Ringgold ID: RIN25323)
› Author Affiliations

A 26-year-old woman, gravida 1 para 0 at 14 weeks 1-day gestation, presented with vaginal spotting and systemic symptoms, including palpitations, shortness of breath, heat intolerance, nausea, and vomiting for two weeks. Workup revealed maternal tachycardia, severe-range blood pressure, elevated β-hCG of 2,442,400 mIU/mL, suppressed TSH, and elevated T4, consistent with thyroid storm with possible preeclampsia with severe features. A transvaginal ultrasound suggested a partial molar pregnancy; this was later confirmed by surgical pathology. This case highlights the rare yet serious complications of hydatidiform mole, in particular, a partial molar pregnancy, including thyroid storm and superimposed preeclampsia, emphasizing the importance of management at a tertiary care center with a multidisciplinary team to optimize maternal outcomes.



Publication History

Received: 24 March 2025

Accepted after revision: 05 May 2025

Accepted Manuscript online:
06 June 2025

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