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CC BY 4.0 · Endosc Int Open 2025; 13: a26255985
DOI: 10.1055/a-2625-5985
Original article

Effect of a distal attachment cuff on adenoma detection rate in screening colonoscopy: Randomized controlled trial in the Spanish population

Autoren

  • Aurora Burgos García

    1   Gastroenterology Department, Endoscopy Unit, La Paz University Hospital, Madrid, Spain (Ringgold ID: RIN16268)
    2   Hospital La Paz Institute for Health Research, IdiPAZ, Biomedical Research Center in Cancer Network (CIBERONC), Madrid, Spain (Ringgold ID: RIN638528)

  • Alberto Herreros de Tejada

    3   Gastroenterology Department, Endoscopy Unit, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN16370)
    4   IDIPHISA, Foundation for Biomedical Research of the Puerta del Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN591905)

  • Carlos Ferre Aracil

    3   Gastroenterology Department, Endoscopy Unit, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN16370)
    4   IDIPHISA, Foundation for Biomedical Research of the Puerta del Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN591905)

  • Oscar Nogales

    5   Gastroenterology Department, Endoscopy Unit, General University Hospital Gregorio Maranon, Madrid, Spain (Ringgold ID: RIN16483)

  • Sofía Parejo

    6   Gastroenterology Department, Endoscopy Unit, Ramón y Cajal University Hospital, Madrid, Spain (Ringgold ID: RIN16507)
    7   IRYCIS, Ramón y Cajal Institute for Health Research, Madrid, Spain (Ringgold ID: RIN537482)

  • Mariana Tavecchia

    1   Gastroenterology Department, Endoscopy Unit, La Paz University Hospital, Madrid, Spain (Ringgold ID: RIN16268)

  • Belen Agudo 

    3   Gastroenterology Department, Endoscopy Unit, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN16370)
    4   IDIPHISA, Foundation for Biomedical Research of the Puerta del Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN591905)

  • Héctor Julián Canaval Zuleta

    8   Gastroenterology Department, Endoscopy Unit, Alcorcon Hospital Foundation, Alcorcon, Spain (Ringgold ID: RIN16432)

  • Angel Cañete Ruiz

    9   Gastroenterology Department, Endoscopy Unit, 12 de Octubre University Hospital, Madrid, Spain (Ringgold ID: RIN16473)

  • Diego De Frutos Rosa

    3   Gastroenterology Department, Endoscopy Unit, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN16370)
    4   IDIPHISA, Foundation for Biomedical Research of the Puerta del Hierro University Hospital of Majadahonda, Majadahonda, Spain (Ringgold ID: RIN591905)

  • Julia Arribas Anta

    9   Gastroenterology Department, Endoscopy Unit, 12 de Octubre University Hospital, Madrid, Spain (Ringgold ID: RIN16473)

  • Beatriz Peñas

    6   Gastroenterology Department, Endoscopy Unit, Ramón y Cajal University Hospital, Madrid, Spain (Ringgold ID: RIN16507)
    7   IRYCIS, Ramón y Cajal Institute for Health Research, Madrid, Spain (Ringgold ID: RIN537482)

  • Rodrigo Borobia

    5   Gastroenterology Department, Endoscopy Unit, General University Hospital Gregorio Maranon, Madrid, Spain (Ringgold ID: RIN16483)

  • Juan L Mendoza

    10   Gastroenterology Department, Endoscopy Unit, San Carlos Clinic Hospital, Madrid, Spain (Ringgold ID: RIN16267)

  • Cristina Bernardo

    8   Gastroenterology Department, Endoscopy Unit, Alcorcon Hospital Foundation, Alcorcon, Spain (Ringgold ID: RIN16432)

  • Pedro De María

    1   Gastroenterology Department, Endoscopy Unit, La Paz University Hospital, Madrid, Spain (Ringgold ID: RIN16268)

  • Natalia Lopez Palacios

    10   Gastroenterology Department, Endoscopy Unit, San Carlos Clinic Hospital, Madrid, Spain (Ringgold ID: RIN16267)

  • Mirella Jiménez Gómez

    11   Gastroenterology Department, Endoscopy Unit, University Hospital of the Princess, Madrid, Spain (Ringgold ID: RIN16517)

  • Guillermo Cacho Acosta

    8   Gastroenterology Department, Endoscopy Unit, Alcorcon Hospital Foundation, Alcorcon, Spain (Ringgold ID: RIN16432)

  • Marta Cuadros Martínez

    1   Gastroenterology Department, Endoscopy Unit, La Paz University Hospital, Madrid, Spain (Ringgold ID: RIN16268)

  • Patricia Mayor Delgado

    1   Gastroenterology Department, Endoscopy Unit, La Paz University Hospital, Madrid, Spain (Ringgold ID: RIN16268)

  • María Ángeles Ruiz Ramírez

    1   Gastroenterology Department, Endoscopy Unit, La Paz University Hospital, Madrid, Spain (Ringgold ID: RIN16268)

  • Ana Royuela Vicente

    12   Bioestatistics Unit, Puerta de Hierro University Hospital of Majadahonda, IDIPHISA-CIBERESP-ISCIII, Madrid, Spain (Ringgold ID: RIN591905)

  • Enrique Rodriguez de Santiago 

    6   Gastroenterology Department, Endoscopy Unit, Ramón y Cajal University Hospital, Madrid, Spain (Ringgold ID: RIN16507)
    7   IRYCIS, Ramón y Cajal Institute for Health Research, Madrid, Spain (Ringgold ID: RIN537482)
    13   Biomedical Research Network Center in the Thematic Area of Liver and Digestive Diseases (CIBEREHD), Madrid, Spain

  • Consuelo Froilán

    1   Gastroenterology Department, Endoscopy Unit, La Paz University Hospital, Madrid, Spain (Ringgold ID: RIN16268)

Gefördert durch: Norgine Clinical Trial: Registration number (trial ID): NCT03436004, Trial registry: ClinicalTrials.gov (http://www.clinicaltrials.gov/), Type of Study: Prospective, Randomized, Multi-Center Study
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Abstract

Background and study aims

Endocuff Vision (EV) is a disposable device designed to improve polyp detection. The primary aim of this study was to evaluate the effect of EV on adenoma detection rate (ADR) and mean number of adenomas per patient (MAP).

Patients and methods

This multicenter randomized controlled trial compared EV-assisted colonoscopy (EAC) and standard colonoscopy (SC). Patients were referred due to a positive fecal immunochemical test (FIT) in a bowel cancer screening program (BCSP), direct screening colonoscopy without prior FIT, surveillance colonoscopy, or family history of colorectal cancer.

Results

In total, 1437 patients (55.9% male; median age, 59 years) were randomized at eight Spanish university hospitals. No significant differences were found in either the ADR (EAC vs. SC, 55.8% vs. 54.3%; P = 0.576) or the MAP (1.60 vs. 1.35; P = 0.03). Compared with SC, EAC was not associated with a significant improvement in detection rates for advanced adenomas, sessile serrated lesions, or advanced sessile serrated lesions. There was no difference in cecal intubation rate but the successful ileal intubation rate, among patients in whom it was attempted, was lower with EAC (64.3% vs. 86.5% with SC; P = 0.001).

Conclusions

EV did not improve either ADR or MAP. EV may increase difficulty of ileal intubation whenever it is attempted.

Keywords

Endoscopy Lower GI Tract - Polyps / adenomas / ... - Colorectal cancer - CRC screening

Supplementary Material



Publikationsverlauf

Eingereicht: 17. Oktober 2024

Angenommen nach Revision: 28. Mai 2025

Accepted Manuscript online:
02. Juni 2025

Artikel online veröffentlicht:
03. November 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Aurora Burgos García, Alberto Herreros de Tejada, Carlos Ferre Aracil, Oscar Nogales, Sofía Parejo, Mariana Tavecchia, Belen Agudo, Héctor Julián Canaval Zuleta, Angel Cañete Ruiz, Diego De Frutos Rosa, Julia Arribas Anta, Beatriz Peñas, Rodrigo Borobia, Juan L Mendoza, Cristina Bernardo, Pedro De María, Natalia Lopez Palacios, Mirella Jiménez Gómez, Guillermo Cacho Acosta, Marta Cuadros Martínez, Patricia Mayor Delgado, María Ángeles Ruiz Ramírez, Ana Royuela Vicente, Enrique Rodriguez de Santiago, Consuelo Froilán. Effect of a distal attachment cuff on adenoma detection rate in screening colonoscopy: Randomized controlled trial in the Spanish population. Endosc Int Open 2025; 13: a26255985.
DOI: 10.1055/a-2625-5985
 

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