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Hamostaseologie
DOI: 10.1055/a-2617-9786
DOI: 10.1055/a-2617-9786
Review Article
The Role of Platelet microRNAs in Cancer
Funding This work was supported by grant B23-RSF162 and Russian Science Foundation grant 23-45-10039.
Abstract
There is strong evidence that platelets significantly contribute to cancer progression. Numerous studies have shown that microRNAs in platelet microvesicles play an important role in different stages of cancer and can serve as new diagnostic and prognostic biomarkers. Since platelet microRNAs have opposing purposes, it is challenging to make clear-cut judgements regarding their involvement in carcinogenesis. However, it is well known that the processes regulated by microRNAs in cancer include cell proliferation, cell death, epithelial–mesenchymal transition, cancer metastasis, and angiogenesis. This review focusses on and summarizes current research in the field of platelet–cancer interactions and discusses the role of platelet microRNAs in cancer development, which is a promising area for future research and therapeutic development.
Author Contributions
Dremuk I.A.: conceptualization, draft preparation, writing, review, and editing.
Shamova E.V.: conceptualization, writing, review, editing, and supervision.
Sveshnikova A.N.: writing, review, editing, and supervision.
Ethics Statement
Ethical approval was not required.
Declaration of Competing Interests
There are no competing interests to disclose.
Data Availability Statement
Not applicable as no new unpublished data were generated for this review.
Publication History
Received: 16 May 2025
Accepted: 21 May 2025
Article published online:
14 July 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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