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DOI: 10.1055/a-2599-9723
A two-stage strategy to facilitate atypical minor duodenal papilla cannulation in pediatric patients: a case series
Supported by: The Science and Technology Commission of Shanghai Municipality of China No. 22Y11921800

A 5-year-old girl diagnosed with chronic pancreatitis, who had previously undergone a failed ERCP. One month later, she was readmitted for a repeat ERCP at our center (case 1). Pancreatography revealed incomplete pancreas divisum with concomitant chronic pancreatitis ([Fig. 1]). Direct cannulation attempts at both the major and minor papillae were unsuccessful. During another attempt at the major papilla, the hydrophilic tip of the guidewire (0.035 inch, Innovax Medical) serendipitously advanced into the minor papilla. After careful evaluation, the “ventral-to-dorsal pancreatic duct” pathway was retained, and the pathway was enlarged with a COOK 6Fr dilation catheter. A 5 Fr-5 cm pancreatic stent (COOK) was then implanted, with its tip located outside the minor papilla and its pigtail segment positioned at the major papilla. The girl developed mild post-ERCP pancreatitis (PEP). Six weeks later, a second-stage ERCP was performed. Under guidance from the stent, a guidewire was inserted through the minor papilla using a sphincterotome, followed by the removal of the pancreatic stent with forceps. The dorsal duct was further dilated using a 7 Fr catheter, and a 7 Fr-7 cm stent was successfully placed. The patient experienced no complications following the second ERCP ([Video 1]).


By implementing this two-stage approach, we successfully replicated the protocols in two subsequent cases (cases 2 and 3). Case 2 developed mild PEP during the first-stage ERCP, and Case 3 manifested hyperamylasemia following each stage. All of the complications demonstrated rapid resolution with conservative management.
Compared to conventional rendezvous techniques, the two-stage ERCP strategy in pediatric populations offers three key advantages:
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Avoidance of papillary trauma: This strategy eliminates shearing injury caused by guidewire traction at the minor papilla, thereby preserving its integrity and minimizing pancreatic duct injury [1].
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Risk mitigation in anatomically challenging cases: It avoids high-risk sphincterotomy of small-based minor papillae within narrow intestinal lumens, particularly due to childrenʼs anatomical constraints [2].
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Operational efficiency: The technique reduces the need for additional instruments (needle knives, endoscopic ultrasonography, etc.) and shortens operative duration, thereby enhancing procedural safety and reducing costs [3] [4].
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Publication History
Article published online:
01 July 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
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References
- 1 Ghattas G, Deviere J, Blancas JM. et al. Pancreatic rendez-vous. Gastrointest Endosc 1992; 38: 590-594
- 2 Inui K, Yoshino J, Miyoshi H. Endoscopic approach via the minor duodenal papilla. Dig Surg 2010; 27: 153-156
- 3 Tsuchiya T, Itoi T, Sofuni A. et al. Endoscopic ultrasonography-guided rendezvous technique. Dige Endosc 2016; 28: 96-101
- 4 Tarnasky PR, Linder JD. Endoscopic minor papilla interventions in patients without pancreas divisum. Gastrointest Endosc 2005; 61: 349-350