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DOI: 10.1055/a-2599-8213
Benigne Prostatahyperplasie mit Blasenentleerungsstörung beim geriatrischen Patienten: Aktive (medikamentöse oder operative) Therapie vs. Katheterversorgung
Benign prostatic hyperplasia with bladder emptying disorder in geriatric patients: active (pharmacological or surgical) treatment vs. catheterization
Zusammenfassung
Epidemiologische Daten zeigen einen klaren Zusammenhang zwischen Alter, Prostatavergrößerung und den damit verbundenen Beschwerden. Das benigne Prostatasyndrom verläuft im Regelfall chronisch progredient und ein erheblicher Teil der BPS-Patienten, die vor der Entscheidung „konservative vs. chirurgische Therapie“ stehen sind hochbetagt und leiden oft an zahlreichen Komorbiditäten, sodass der Grundsatz des „nihil nocere“ besonders ernst zu nehmen ist. Die Nutzen-Risiko-Abschätzung ist sowohl bei der medikamentösen als auch bei der chirurgischen Therapie mit großer Sorgfalt vorzunehmen. Nach Sichtung der Literatur inclusive der einschlägigen Leitlinien kommt der Autor zu dem Schluss, dass es bei entsprechender Indikation kaum Gründe gibt, geriatrischen Patienten eine der zahlreichen interventionellen Optionen zu versagen, vielleicht mit der Ausnahme des tatsächlich bereits pflegebedürftigen Patientenkollektivs.
Abstract
Epidemiological data demonstrate a clear association between age, prostatic enlargement, and the associated symptoms. Benign prostatic syndromes usually take a chronic progressive course, and a significant share of BPS patients faced with the decision “conservative vs. surgical treatment” are of advanced age and suffer from numerous comorbidities, which means that the principle of “nihil nocere” must be given special consideration. A benefit-risk assessment must be carried out very carefully both for pharmacological and surgical treatment. Having reviewed the literature, including the relevant guidelines, the author concludes that, if a relevant indication exists, there are hardly any reasons to deny geriatric patients one of the numerous interventional options, perhaps with the exception of a patient population that is already in need of long-term care.
Schlüsselwörter
Benigne Prostatahyperplasie - geriatrischer Patient - Obstruktion - Therapie - KatheterKeywords
geriatric patient - benign prostatic enlargement - treatment - indwelling catheter - obstructionPublication History
Received: 02 April 2025
Accepted after revision: 28 April 2025
Article published online:
05 June 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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Literatur
- 1 Berges R, Oelke M. Age-stratified normal values for prostate volume, PSA, maximum urinary flow rate, IPSS, and other LUTS/BPH indicators in the German male community-dwelling population aged 50 years or older. World J Urol 2011; 29: 171-178
- 2 Berges RR, Pientka L, Hofner K. et al. Male lower urinary tract symptoms and related health care seeking in Germany. Eur Urol 2001; 39: 682-687
- 3 Berry SJ, Coffey DS, Walsh PC. et al. The development of human benign prostatic hyperplasia with age. J Urol 1984; 132: 474-479
- 4 Gacci M, Corona G, Vignozzi L. et al. Metabolic syndrome and benign prostatic enlargement: a systematic review and meta-analysis. BJU Int 2015; 115: 24-31
- 5 Russo GI, Castelli T, Urzi D. et al. Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis. Aging Male 2015; 18: 207-216
- 6 Zou C, Gong D, Fang N. et al. Meta-analysis of metabolic syndrome and benign prostatic hyperplasia in Chinese patients. World J Urol 2016; 34: 281-289
- 7 Emberton M, Andriole GL, de la Rosette J. et al. Benign prostatic hyperplasia: a progressive disease of aging men. Urology 2003; 61: 267-273
- 8 McConnell JD, Bruskewitz R, Walsh P. et al. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group. N Engl J Med 1998; 338: 557-563
- 9 Roehrborn CG, McConnell J, Bonilla J. et al. Serum prostate specific antigen is a strong predictor of future prostate growth in men with benign prostatic hyperplasia. PROSCAR long-term efficacy and safety study. J Urol 2000; 163: 13-20
- 10 Emberton M, Fitzpatrick JM, Garcia-Losa M. et al. Progression of benign prostatic hyperplasia: systematic review of the placebo arms of clinical trials. BJU Int 2008; 102: 981-986
- 11 Oelke M, Kirschner-Hermanns R, Thiruchelvam N. et al. Can we identify men who will have complications from benign prostatic obstruction (BPO)? ICI-RS 2011. Neurourol Urodyn 2012; 31: 322-326
- 12 Tjia J, Velten SJ, Parsons C. et al. Studies to reduce unnecessary medication use in frail older adults: a systematic review. Drugs Aging 2013; 30: 285-307
- 13 Fusco F, Creta M, De Nunzio C. et al. Alpha-1 adrenergic antagonists, 5-alpha reductase inhibitors, phosphodiesterase type 5 inhibitors, and phytotherapic compounds in men with lower urinary tract symptoms suggestive of benign prostatic obstruction: A systematic review and meta-analysis of urodynamic studies. Neurourol Urodyn 2018; 37: 1865-1874
- 14 Sakalis V, Gkotsi A, Charpidou D. et al. The effect of pharmacotherapy on prostate volume, prostate perfusion and prostate-specific antigen (prostate morphometric parameters) in patients with lower urinary tract symptoms and benign prostatic obstruction. A systematic review and meta-analysis. Cent European J Urol 2021; 74: 388-421
- 15 Roehrborn CG, Siami P, Barkin J. et al. The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol 2010; 57: 123-131
- 16 Djavan B, Marberger M. A meta-analysis on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction. Eur Urol 1999; 36: 1-13
- 17 Welk B, McArthur E, Fraser LA. et al. The risk of fall and fracture with the initiation of a prostate-selective alpha antagonist: a population based cohort study. BMJ 2015; 351: h5398
- 18 Chu PSK, Leung CLH, Cheung MH. et al. Hong Kong Geriatrics Society and Hong Kong Urological Association consensus on personalised management of male lower urinary tract symptoms in the era of multiple co-morbidities and polypharmacy. Hong Kong Med J 2021; 27: 127-139
- 19 Storr-Paulsen A, Norregaard JC, Borme KK. et al. Intraoperative floppy iris syndrome (IFIS): a practical approach to medical and surgical considerations in cataract extractions. Acta Ophthalmol 2009; 87: 704-708
- 20 Roehrborn CG, McConnell JD, Lieber M. et al. Serum prostate-specific antigen concentration is a powerful predictor of acute urinary retention and need for surgery in men with clinical benign prostatic hyperplasia. PLESS Study Group. Urology 1999; 53: 473-480
- 21 Oelke M, Becher K, Castro-Diaz D. et al. Appropriateness of oral drugs for long-term treatment of lower urinary tract symptoms in older persons: results of a systematic literature review and international consensus validation process (LUTS-FORTA 2014). Age Ageing 2015; 44: 745-755
- 22 Skeldon SC, Macdonald EM, Law MR. et al. The Cardiovascular Safety of Dutasteride. J Urol 2017; 197: 1309-1314
- 23 Kaplan SA, Holtgrewe HL, Bruskewitz R. et al. Comparison of the efficacy and safety of finasteride in older versus younger men with benign prostatic hyperplasia. Urology 2001; 57: 1073-1077
- 24 Wei L, Lai EC, Kao-Yang YH. et al. Incidence of type 2 diabetes mellitus in men receiving steroid 5alpha-reductase inhibitors: population based cohort study. BMJ 2019; 365: l1204
- 25 Jensen KM, Jorgensen TB, Mogensen P. Long-term predictive role of urodynamics: an 8-year follow-up of prostatic surgery for lower urinary tract symptoms. Br J Urol 1996; 78: 213-218
- 26 Kim M, Jeong CW, Oh SJ. Diagnostic value of urodynamic bladder outlet obstruction to select patients for transurethral surgery of the prostate: Systematic review and meta-analysis. PLoS One 2017; 12: e0172590
- 27 Cornu JN. EAU guidelines on non neurogenic male lower urinary tract symptoms (LUTS). In: Office EAoUG ed: Non Oncology Guidelines. 2024
- 28 Lotterstatter M, Seklehner S, Wimpissinger F. et al. Transurethral resection of the prostate in 85+ patients: a retrospective, multicentre study. World J Urol 2022; 40: 3015-3020
- 29 Brierly RD, Mostafid AH, Kontothanassis D. et al. Is transurethral resection of the prostate safe and effective in the over 80-year-old?. Ann R Coll Surg Engl 2001; 83: 50-53
- 30 Evrard PL, Mongiat-Artus P, Desgrandchamps F. Morbi-mortality of transurethral resection of the prostate in patients aged 75 and over. Prog Urol 2017; 27: 312-318
- 31 Ilkjaer LB, Lund L, Nielsen KT. Outcome of transurethral prostatectomy in men over 80 years. Scand J Urol Nephrol 1998; 32: 270-272
- 32 Suskind AM, Walter LC, Zhao S. et al. Functional Outcomes After Transurethral Resection of the Prostate in Nursing Home Residents. J Am Geriatr Soc 2017; 65: 699-703
- 33 Bayraktar N, Baseskioglu AB. Holmium Laser Enucleation of the Prostate (HoLEP) Versus Transurethral Resection of the Prostate (TURP) in Elderly Patients: Insights Into Recovery, Complications, and Risk Factors. Cureus 2024; 16: e7638 4
- 34 Castellani D, Pirola GM, Gasparri L. et al. Are Outcomes of Thulium Laser Enucleation of the Prostate Different in Men Aged 75 and Over? A Propensity Score Analysis. Urology 2019; 132: 170-176
- 35 McVary KT, Gange SN, Gittelman MC. et al. Erectile and Ejaculatory Function Preserved With Convective Water Vapor Energy Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: Randomized Controlled Study. J Sex Med 2016; 13: 924-933
- 36 Roehrborn CG, Gange SN, Gittelman MC. et al. Convective Thermal Therapy: Durable 2-Year Results of Randomized Controlled and Prospective Crossover Studies for Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia. J Urol 2017; 197: 1507-1516
- 37 Spinos T, Katafigiotis I, Leotsakos I. et al. Rezum water vapor therapy for the treatment of patients with urinary retention and permanent catheter dependence secondary to benign prostate hyperplasia: a systematic review of the literature. World J Urol 2023; 41: 413-420
- 38 Jung JH, Reddy B, McCutcheon KA. et al. Prostatic urethral lift for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia. Cochrane Database Syst Rev 2019; 5: CD012832
- 39 Roehrborn CG, Barkin J, Gange SN. et al. Five year results of the prospective randomized controlled prostatic urethral L.I.F.T. study. Can J Urol 2017; 24: 8802-8813
- 40 Chughtai B, Elterman D, Shore N. et al. The iTind Temporarily Implanted Nitinol Device for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Multicenter, Randomized, Controlled Trial. Urology 2021; 153: 270-276
- 41 Kaplan SA, Moss J, Freedman S. et al. The PINNACLE Study: A Double-blind, Randomized, Sham-controlled Study Evaluating the Optilume BPH Catheter System for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia. J Urol 2023; 210: 500-509
- 42 Chen DC, Qu L, Webb H. et al. Aquablation in men with benign prostate hyperplasia: A systematic review and meta-analysis. Curr Urol 2023; 17: 68-76