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DOI: 10.1055/a-2572-0778
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Study on the synthesis and biological activity of trifluoroacetamide promoted by base without transition metal participation

Xing Tian
1   School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China (Ringgold ID: RIN12401)
,
Jin Zhang
2   School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, China (Ringgold ID: RIN71179)
,
Yang Li 
3   School of Environmental and Chemical Engineering, Xi’an Polytechnic University, Xi’an, China
› InstitutsangabenGefördert durch: National Natural Science Foundation of China GZ-1645
Gefördert durch: Key Research & Development Project 2022GY-195,2023-YBGY-183
Gefördert durch: Shaanxi Provincial Department of Education Science and Technology 23JC035
Gefördert durch: Basic Research Project of Natural Science of Shaanxi Province 2021JLM-30
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We report a coupling reaction without transition metal catalysis, introducing the efficient synthesis of trifluoroacetylaniline compounds using dibromotrifluoroacetone as the trifluoroacetylation reagent. The reaction conditions are mild, requiring only an equivalent amount of base to achieve this reaction. The substrate has good tolerance for functional groups and a wide range of substrates. More importantly, we studied the biological bactericidal activity of two compounds and found that com-pound 3z has a good bactericidal effect, with a bactericidal rate of over 99% against Bacillus subtilis. We firmly believe that this research result will provide a good technical foundation for later drug molecular screening.



Publikationsverlauf

Eingereicht: 04. Februar 2025

Angenommen nach Revision: 31. März 2025

Accepted Manuscript online:
01. April 2025

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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