Abstract
Objective
Chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH) is a rare benign
growth within the nasal cavity or paranasal sinuses. We aim to highlight the pathogenesis
and clinical presentation of an extremely rare benign mass within the nasal cavity
and demonstrate the workup, diagnosis, and management of this rare lesion, as well
as review the literature.
Methods
Retrospective review of a patient presenting with COREAH of the sinonasal cavity treated
at a single tertiary academic medical center. The MEDLINE database was additionally
searched for all case series or reports of sinonasal or skull base COREAH.
Results
A total of sixteen articles were identified for review. In addition to the current
case, a total of nineteen patients were identified in literature found to have sinonasal
or skull base COREAH. The most common primary sites of attachment were the lateral
nasal wall and posterior septum. Only two cases were identified with skull base attachment.
Computed topography (CT) was employed in 84.2% of patients, and CT with MRI was utilized
in 26.3% of patients. Endoscopic resection was performed in 100% of patients, with
one recurrence reported in the literature and one incomplete resection requiring revision
surgery.
Conclusion
COREAH is an extremely rare hamartoma consisting of glandular proliferation with cartilaginous
and osseous stroma. COREAH is symptomatic in 100% of reported cases in the literature,
and complete surgical resection is often curative. Our case represents the longest
follow-up reported with 4 years postoperatively revealing no growth or recurrence
of COREAH.
Keywords
COREAH - chondro-osseous respiratory epithelial adenomatoid hamartoma - sinonasal
mass
