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CC BY 4.0 · J Neurol Surg Rep 2025; 86(02): e50-e56
DOI: 10.1055/a-2556-0732
Case Report

Chondro-Osseous Respiratory Epithelial Adenomatoid Hamartoma of the Skull Base: Report of a Case and Literature Review

Monica S. Trent 
1   Department of Otolaryngology – Head and Neck Surgery, University of California, Irvine Medical Center, Orange, California, United States
,
Beverly Wang
2   Department of Anatomic and Clinical Pathology, Cytopathology, University of California, Irvine Medical Center, Orange, California, United States
,
Edward C. Kuan 
1   Department of Otolaryngology – Head and Neck Surgery, University of California, Irvine Medical Center, Orange, California, United States
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Abstract

Objective

Chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH) is a rare benign growth within the nasal cavity or paranasal sinuses. We aim to highlight the pathogenesis and clinical presentation of an extremely rare benign mass within the nasal cavity and demonstrate the workup, diagnosis, and management of this rare lesion, as well as review the literature.

Methods

Retrospective review of a patient presenting with COREAH of the sinonasal cavity treated at a single tertiary academic medical center. The MEDLINE database was additionally searched for all case series or reports of sinonasal or skull base COREAH.

Results

A total of sixteen articles were identified for review. In addition to the current case, a total of nineteen patients were identified in literature found to have sinonasal or skull base COREAH. The most common primary sites of attachment were the lateral nasal wall and posterior septum. Only two cases were identified with skull base attachment. Computed topography (CT) was employed in 84.2% of patients, and CT with MRI was utilized in 26.3% of patients. Endoscopic resection was performed in 100% of patients, with one recurrence reported in the literature and one incomplete resection requiring revision surgery.

Conclusion

COREAH is an extremely rare hamartoma consisting of glandular proliferation with cartilaginous and osseous stroma. COREAH is symptomatic in 100% of reported cases in the literature, and complete surgical resection is often curative. Our case represents the longest follow-up reported with 4 years postoperatively revealing no growth or recurrence of COREAH.

Keywords

COREAH - chondro-osseous respiratory epithelial adenomatoid hamartoma - sinonasal mass


Publication History

Received: 12 October 2024

Accepted: 24 December 2024

Accepted Manuscript online:
12 March 2025

Article published online:
03 April 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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