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CC BY 4.0 · Sustainability & Circularity NOW 2025; 02: a25409377
DOI: 10.1055/a-2540-9377
DOI: 10.1055/a-2540-9377
Original Article
Transitioning to a Circular Economy Safely and Sustainably: A Qualitative Exploration of System Barriers and Drivers for Industrial Biotechnology in the EU
Funding Information This research was partly funded by the Strategic Programme of the Netherlands National Institute for Public Health and the Environment (RIVM), grant number S/0300003.
Abstract
Innovations in industrial biotechnology promise great potential for contributing to the circular economy as they can reduce our dependence on fossil-based raw materials. However, their environmental impacts and sustainability benefits can differ greatly. Therefore, it is important to consider the values of safety and sustainability when designing innovative applications for the circular economy transition.
Transitions like the one from a linear to a circular economy are shaped by the dynamics between political, societal, economic, and technological developments. Insights from actors working with industrial biotechnology innovation or policies are useful to explore the barriers and drivers of legislation, culture, and the market in a circular economy transition.
Results indicate that sustainability legislation, genetically modified organism (GMO) legislation, governmental policies, and societal resistance hinder early research and development and appear to delay sustainable industrial biotechnology applications from entering the European market. But the tide might be changing. As market and societal actors are learning how to navigate the tensions between safety and sustainability, they more openly underscore the sustainability benefits of using genetically modified microorganisms over potential risks to environmental and human safety. European policy and legislation are beginning to recognize the need for integrated policies that align safety, sustainability, and circularity needs.
Keywords
Industrial biotechnology - Netherlands - Circular economy - Transitions - European Union - SSbDPublication History
Received: 30 October 2024
Accepted after revision: 06 February 2025
Accepted Manuscript online:
17 February 2025
Article published online:
21 March 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Bibliographical Record
Denise Flaherty, Iduna Hoefnagel, Petra A. M. Hogervorst, Pim Klaassen. Transitioning to a Circular Economy Safely and Sustainably: A Qualitative Exploration of System Barriers and Drivers for Industrial Biotechnology in the EU. Sustainability & Circularity NOW 2025; 02: a25409377.
DOI: 10.1055/a-2540-9377
Denise Flaherty, Iduna Hoefnagel, Petra A. M. Hogervorst, Pim Klaassen. Transitioning to a Circular Economy Safely and Sustainably: A Qualitative Exploration of System Barriers and Drivers for Industrial Biotechnology in the EU. Sustainability & Circularity NOW 2025; 02: a25409377.
DOI: 10.1055/a-2540-9377
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References
- 1
Commission E.
A European Green Deal | European Commission. European Commission [Internet], 2019
[cited 2021 Mar 18]; 24. Available from: https://ec.europa.eu/info/strategy/priorities-2019-2024/european-green-deal_en
- 2
OECD.
Policy Coherence for Sustainable Development in the SDG Framework Shaping Targets
and Monitoring Progressthe-sustainable-development-goals-of-the-post-2015-agenda-comments-on-the-owg-and-sdsn-proposals
[Internet], 2015 [cited 2021 May 27]. Available from: http://www.die-gdi.de/publikationen/manuskripte-oeffentlich/article/
- 3
Circular economy.
Rijksoverheid.nl [Internet]. [cited 2021 Mar 17]. Available from: https://www.rijksoverheid.nl/onderwerpen/circulaire-economie
- 4
National Agreement on the Circular Economy.
Discussion document, Government.nl [Internet]. [cited 2021 Jun 23]. Available from:
https://www.government.nl/topics/circular-economy/documents/discussion-documents/2017/01/24/national-agreement-on-the-circular-economy
- 5
Government of the Netherlands.
A circular economy in the Netherlands by 2050, 2016 72. Available from: https://www.government.nl/binaries/government/documents/policy-notes/2016/09/14/a-circular-economy-in-the-netherlands-by-2050/17037+Circulaire+Economie_EN.PDF
- 6
European Commission.
Biotechnology, Internal Market, Industry, Entrepreneurship and SMEs [Internet]. [cited
2021 Mar 29]. Available from: https://ec.europa.eu/growth/sectors/biotechnology_en
- 7
Ellen MacArthur Foundation.
Towards the Circular Economy Opportunities for the consumer goods sector 2 Pre-print
version, 2013
- 8
Arbige MV,
Shetty JK,
Chotani GK.
Industrial Enzymology: The Next Chapter [Internet]. Vol. 37, Trends in Biotechnology,
2019 [cited 2021 May 5]. pp 1355–1366. Available from: https://doi.org/10.1016/j.tibtech.2019.09.010
- 9 Ribeiro B, Shapira P. Anticipating governance challenges in synthetic biology: Insights from biosynthetic menthol. Technol. Forecast Soc. Change 2019; 139: 311-320
- 10 Yang J, Yang Y, Wu WM, Zhao J, Jiang L. Evidence of polyethylene biodegradation by bacterial strains from the guts of plastic-eating waxworms. Environ. Sci. Technol. 2014; 48 (23) 13776-13784
- 11
Ellen Macarthur.
The biological cycle of the butterfly diagram [Internet]. [cited 2023 May 25]. Available
from: https://ellenmacarthurfoundation.org/articles/the-biological-cycle-of-the-butterfly-diagram
- 12 Fröhling M, Hiete M. Sustainability and life cycle assessment in industrial biotechnology [Internet]. In Advances in Biochemical Engineering/Biotechnology. Scheper T. Ed.; Springer; Cham: 2020. Vol 173. pp 1-366
- 13 Loeffler M, Hinrichs J, Moß K, Henkel M, Hausmann R, Kruse A. et al. Bioeconomy: Shaping the Transition to a Sustainable, Biobased Economy. In Bioeconomy: Shaping the Transition to a Sustainable, Biobased Economy. Lesandowski I. Ed.; 2017 pp 177-228
- 14 Scaife MA, Smith AG. Towards developing algal synthetic biology. Biochem. Soc. Trans. 2016; 44 (03) 716-722
- 15 French KE. Harnessing synthetic biology for sustainable development. Nat. Sustainability 2019; 2 (04) 250-252
- 16
COGEM C.
Trendanalyse Biotechnologie [Internet], 2016 p 36 Available from: http://cogem.net/index.cfm/nl/publicaties/publicatie/trendanalyse-biotechnologie-2016-regelgeving-ontregeld
- 17
European Parliament.
Directive 2009/41/EC on the contained use of genetically modified micro-organisms.
May 6, 2009
- 18
Ministry of Infrastructure and Environment N.
Regeling – Besluit genetisch gemodificeerde organismen milieubeheer 2013 – BWBR0035090
[Internet] 2022 Available from: https://wetten.overheid.nl/BWBR0035090/2022-10-26
- 19
Ministry of Infrastructure and Water Management N.
Regeling genetisch gemodificeerde organismen milieubeheer 2013 – BWBR0035072 [Internet],
2024 [cited 2024 Oct 29]. Available from: https://wetten.overheid.nl/BWBR0035072/2024-07-01
- 20
Hogervorst PA. M,
van den Akker HC. M,
Glandorf DC. M,
Klaassen P,
van der Vlugt CJ. V,
Westra J.
Assessment of human health and environmental risks of new developments in modern biotechnology
[Internet]. Bilthoven, 2018 [cited 2023 Jun 7]. Available from: www.rivm.nl/en
- 21
Mampuys R.
The Deadlock in European GM Crop Authorisations as a Wicked Problem by Design A need
for Repoliticisation of the Decision-making Process, 2021 (January)
- 22 Trump BD. Synthetic biology regulation and governance: Lessons from TAPIC for the United States, European Union, and Singapore. Health Policy 2017; 121 (11) 1139-1146
- 23
Friends of the Earth.
Report: Synthetic Biofuels Not a Solution to the Climate Crisis [Internet], 2010 [cited
2023 Jun 19]. Available from: https://foe.org/news/2010-09-report-synthetic-biofuels-not-a-solution-to-the-clim/
- 24 Prakash D, Verma S, Bhatia R, Tiwary BN. Risks and Precautions of Genetically Modified Organisms. ISRN Ecol. 2011; 1-13
- 25
Blancke S.
Why People Oppose GMOs Even Though Science Says They Are Safe – Scientific American
[Internet], 2015 [cited 2021 Mar 18]. Available from: https://www.scientificamerican.com/article/why-people-oppose-gmos-even-though-science-says-they-are-safe/
- 26 Asveld L, Osseweijer P, Posada JA. Societal and ethical issues in industrial biotechnology. In Advances in Biochemical Engineering/Biotechnology. Springer; 2020. pp 121-141
- 27 Anyshchenko A. The Precautionary Principle in EU Regulation of GMOs: Socio-Economic Considerations and Ethical Implications of Biotechnology. J. Agric. Environ. Ethics 2019; 32 (5–6) 855-872
- 28 Jasanoff S. In the democracies of DNA: Ontological uncertainty and political order in three states. New Genet. Soc. 2005; 24 (02) 139-156
- 29
Asveld L,
Stemerding D.
Algae oil on trial: Conflicting views of technology and nature, 2016: 1-33
- 30 Menten F, Chèze B, Patouillard L, Bouvart F. A review of LCA greenhouse gas emissions results for advanced biofuels: The use of meta-regression analysis. Renewable Sustainable Energy Rev. 2013; 26: 108-134
- 31 Lindner JP, Beck T, Bos U, Albrecht S. Assessing land use and biodiversity impacts of industrial biotechnology. Adv. Biochem. Eng. Biotechnol. 2020; 173: 233-54
- 32 Venkatesh A, Posen ID, MacLean HL, Chu PL, Griffin WM, Saville BA. Environmental aspects of biotechnology. Adv. Biochem. Eng. Biotechnol. 2020; 173: 77-119
- 33
Secretariat of the Convention on Biological Diversity.
CARTAGENA PROTOCOL [Internet], Montreal, 2000 [cited 2023 Jun 7]. Available from:
http://www.biodiv.org
- 34
Judgement of the Court Case C-528/16 [Internet].
2018 [cited 2023 Jun 7]. Available from: https://curia.europa.eu/juris/document/document.jsf?docid=204387&doclang=EN
- 35 Rockström J, Gupta J, Qin D, Lade SJ, Abrams JF, Andersen LS. et al. Safe and just Earth system boundaries. Nature 2023; 619 (7968) 102-111 Available from: https://www.nature.com/articles/s41586-023-06083-8
- 36
European Commission.
Designing safe and sustainable products requires a new approach for chemicals – European
Environment Agency [Internet], 2021 [cited 2021 Apr 9]. Available from: https://www.eea.europa.eu/themes/human/chemicals/delivering-products-that-are-safe
- 37
Caldeira C,
Farcal R,
Garmendia Aguirre I,
Mancini L,
Tosches D,
Amelio A.
et al.
Safe and sustainable by design chemicals and materials – Framework for the definition
of criteria and evaluation procedure for chemicals and materials, EUR 31100 EN, 2022
- 38 Circular economy – Safe-by-Design [Internet]. [cited 2021 Mar 17]. Available from:
https://www.safe-by-design-nl.nl/home+english/circular+economy/default.aspx
- 39
RIVM.
SPR Circular Economy, 2019 p 28
- 40
Subramanian V,
Guinée J.
Implementing Safe by Design in Product Development through Combining Risk Assessment
and Life Cycle Assessment, 2021
- 41 Broeren ML. M, Zijp MC, Waaijers-van der Loop SL, Heugens EH. W, Posthuma L, Worrell E. et al. Environmental assessment of bio-based chemicals in early-stage development: a review of methods and indicators. Biofuels, Bioprod. Biorefin. 2017; 11 (04) 701-718
- 42 Grin J. ‘Doing’ system innovations from within the heart of the regime. J. Environ. Policy Plann. 2020; 22 (05) 682-694
- 43 Loorbach D. Transition management for sustainable development: A prescriptive, complexity-based governance framework. Governance 2010; 23 (01) 161-183
- 44 Meadows DH, Wright D. Thinking in Systems: A Primer. Chelsea Green Publishing; White River Junction, Vermont: 2008
- 45 Bouchaut B, Asveld L. Safe-by-Design: Stakeholders’ Perceptions and Expectations of How to Deal with Uncertain Risks of Emerging Biotechnologies in the Netherlands. Risk Anal. 2020; 40 (08) 1632-1644
- 46
Milios L.
Policies for Resource Efficient and Effective Solutions : A review of concepts, current
policy landscape and future policy considerations for the transition to a Circular
Economy, 2016 (September 2016): 80. Available from: https://lup.lub.lu.se/record/d4fef157-6876-47c5-94bf-3b3699007fdc
- 47 Gale GA. R, Schiavon Osorio AA, Mills LA, Wang B, Lea-Smith DJ, McCormick AJ. Emerging Species and Genome Editing Tools: Future Prospects in Cyanobacterial Synthetic Biology. Microorganisms 2019; 7 (10) 409
- 48 Dosi G. Sources, Procedures, and Microeconomic Effects of Innovation. Source. J. Econ. Lit. 1988; 26 (03) 1120-1171
- 49 Lundvall BÅ. The Learning Economy and The Economics of Hope. 1 st ed.; ANTHEM PRESS; 2016
- 50 Pyka A, Prettner K. Economic growth, development, and innovation: The transformation towards a knowledge-based bioeconomy. In Bioeconomy: Shaping the Transition to a Sustainable, Biobased Economy. Springer International Publishing; 2017. pp 329-40
- 51 Jasanoff S. States of knowledge: The co-production of science and the social order. States of Knowledge: The Co-Production of Science and the Social Order. Routledge Taylor & Francis Group; 2004. pp 1-317
- 52 Biotechnology. Safe-by-Design [Internet]. [cited 2023 May 17]. Available from: https://www.safe-by-design-nl.nl/home+english/biotechnology/default.aspx
- 53 Kansen en risico’s van biotechnologie. Biotechnologie, Rijksoverheid.nl [Internet].
[cited 2023 May 17]. Available from: https://www.rijksoverheid.nl/onderwerpen/biotechnologie/kansen-en-risicos-biotechnologie
- 54 Krouwel SJ. C, Dierickx ER, Heesterbeek S, Klaassen P. Adopting Safe-by-Design in Science and Engineering Academia: The Soil May Need Tilling. Int. J. Environ. Res. Public Health 2022; 19: 2075 Available from: https://www.mdpi.com/1660-4601/19/4/2075/htm
- 55 Geels FW. From sectoral systems of innovation to socio-technical systems: Insights about dynamics and change from sociology and institutional theory. Res. Policy 2004; 33 (6–7) 897-920
- 56
Rip A,
Kemp R.
Technol. Change 1998; 327-399
- 57 Geels FW. Technological transitions as evolutionary reconfiguration processes: a multi-level perspective and a case-study. Res. Policy 2002; 31 (8–9) 1257-1274
- 58 The Just Transition Mechanism: making sure no one is left behind, European Commission
[Internet]. [cited 2021 Jun 29]. Available from: https://ec.europa.eu/info/strategy/priorities-2019-2024/european-green-deal/actions-being-taken-eu/just-transition-mechanism_en
- 59 OECD. Meeting Policy Challenges for a Sustainable Bioeconomy. Meeting Policy Challenges for a Sustainable Bioeconomy. OECD Publishing; Paris: 2018
- 60
Leydesdorff L.
The Knowledge-Based Economy and the Triple Helix Model. [cited 2023 Jun 13]; Available
from: http://europa.eu.int/comm/research/era/pdf/com2000-6-en.pdf
- 61 Creswell JW. Qualitative inquiry and research design: Choosing among five traditions. Qualitative inquiry and research design: Choosing among five traditions. Sage Publications, Inc.; Thousand Oaks, CA, US: 1998. pp 403-410
- 62 Verschuren P, Doorewaard H. Designing a Research Project. 2 nd ed.; Eleven International Publishing; The Hague: 2010
- 63 Brinkman S, Kvale S. In Doing Interviews. Flick U. (Ed.), Sage; 2018. p 208
- 64 Gray DE. Doing Research in the Real World. 4 th ed.; Seaman J, Fila C, Owen A, Statham C, Bedford T. (Eds.), SAGE Publications Ltd.; 2018. p 813
- 65 Braun V, Clarke V. Using thematic analysis in psychology. Qual. Res. Psychol. 2006; 3 (02) 77-101 Available from: https://www.tandfonline.com/action/journalInformation?journalCode=uqrp20
- 66
Nowell LS,
Norris JM,
White DE,
Moules NJ.
Thematic Analysis: Striving to Meet the Trustworthiness Criteria. Int. J. Qual. Methods.
Available from: https://journals.sagepub.com/doi/pdf/10.1177/1609406917733847
- 67 Saviano M, Barile S, Farioli F, Orecchini F. Strengthening the science–policy–industry interface for progressing toward sustainability: a systems thinking view. Sustainable Sci. 2019; 14 (06) 1549-1564
- 68 Marris C. Public views on GMOs: deconstructing the myths. Stakeholders in the GMO debate often describe public opinion as irrational. But do they really understand the public?. EMBO Rep. 2001; 2 (07) 545-548 Available from: https://pubmed.ncbi.nlm.nih.gov/11463731/
- 69 Legge JS, Durant RF. Public Opinion, Risk Assessment, and Biotechnology: Lessons from Attitudes toward Genetically Modified Foods in the European Union. Rev. Policy Res. 2010; 27 (01) 59-76
- 70 Hirschman AO. Exit, Voice, and Loyalty: Responses to Decline in Firms, Organizations, and States. 1970 Vol. 25.
- 71
Foote N.
No to pesticide cuts? No gene editing proposal, Commission official warns – EURACTIV.com EURACTIV [Internet], 2023 May 15 [cited 2023 Jun 7]; Available from: https://www.euractiv.com/section/agriculture-food/news/no-to-pesticide-cuts-no-gene-editing-proposal-commission-official-warns/
- 72 Asin-Garcia E, Robaey Z, Kampers LF. C, Martins dos Santos VA. P. Exploring the Impact of Tensions in Stakeholder Norms on Designing for Value Change: The Case of Biosafety in Industrial Biotechnology. Sci. Eng. Ethics 2023; 29 (02) 9
- 73 De Witt A, Osseweijer P, Pierce R. Understanding public perceptions of biotechnology through the “Integrative Worldview Framework”. Publ. Understanding Sci. 2017; 26 (01) 70-88
- 74 Unilever to Eliminate Fossil Fuels in Cleaning Products by 2030 as Part of €1 Billion
Clean Future Investment – DutchNews.nl. Dutch News [Internet], 2020 Sep 1 [cited 2023
May 30]; Available from: https://www.dutchnews.nl/businesswire/unilever-to-eliminate-fossil-fuels-in-cleaning-products-by-2030-as-part-of-e1-billion-clean-future-investment/
- 75
Badger J.
Why Unilever is treading carefully with ‘cow-free dairy’ products, Comment & Opinion,
The Grocer [Internet], 2022 [cited 2023 May 25]. Available from: https://www.thegrocer.co.uk/the-grocer-blog-daily-bread/why-unilever-is-treading-carefully-with-cow-free-dairy-products/673899.article
- 76 Unilever. Unilever’s Position on Genetically Modified Crops
- 77
DSM.
DSM’s position on Industrial Biotechnology, 2020
- 78
European Commission.
Communication from the Commission to the European Parliament, The Council, The European
Economic and Social Committee and the Committee of the Regions Building the future
with nature: Boosting Biotechnology and Biomanufacturing in the EU 1, 2024 Mar 20
[cited 2024 Oct 29]; Available from: https://www.statista.com/statistics/1246614/top-countries-share-of-global-biotech-value/
- 79 European Coatings [Internet]. Formaldehyde-free adhesive for industrial use in the
wood-processing industry, European Coatings. 2017 [cited 2023 May 22]. Available from:
https://www.european-coatings.com/articles/archiv/formaldehyde_free-adhesive-for-industrial-use-in-the-wood_processing-industry
- 80 Liew FE, Nogle R, Abdalla T, Rasor BJ, Canter C, Jensen RO. et al. Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale. Nat. Biotechnol. 2022; 40 (03) 335-44 Available from: https://www.nature.com/articles/s41587-021-01195-w
- 81
Urquhart J.
Reprogrammed bacterium turns carbon dioxide into chemicals on industrial scale, Research,
Chemistry World. Chemistry World [Internet], 2022 Mar 2 [cited 2023 May 23]; Available
from: https://www.chemistryworld.com/news/reprogrammed-bacterium-turns-carbon-dioxide-into-chemicals-on-industrial-scale/4015307.article
- 82 Keasling JD. Synthetic biology and the development of tools for metabolic engineering. Metab. Eng. 2012; 14 (03) 189-195 Available from: www.elsevier.com/locate/ymben
- 83
VNO-NCW.
Toekomstpact Biotechnologie Nederland 2025, 2021 p 13
- 84
European Commission.
Study on the status of new genomic techniques under Union law and in light of the
Court of Justice ruling in Case C-528/16. Vol. 117, SWD(2021) 92 final, 2021
- 85 Bertheau Y. Advances in identifying GM plants: toward the routine detection of “hidden” and “new” GMOs. In Developing smart-agrifood supply chains: using technology to improve safety and quality. [Internet]; Burleigh Dodds Science Publishing; 2021. [cited 2023 Jun 7] Available from https://hal.inrae.fr/hal-03318891
- 86 European Commission. Proposal for a Regulation of the European Parliament and of the Council on plants obtained by certain new genomic techniques and their food and feed, and amending Regulation (EU) 2017/625. [Internet], Brussels, 2023 Jul [cited 2024 Oct 29]. Report No.: 52023PC0411. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex:52023PC0411
- 87
Europabio.
EFIB Rotterdam Statement 2023 – Europabio [Internet], 2023 [cited 2024 Oct 29]. Available
from: https://www.europabio.org/efib-rotterdam-statement-2023/
- 88 Delmas M, Hoffmann VH, Kuss M. Under the tip of the iceberg: Absorptive capacity, environmental strategy, and competitive advantage. Bus. Soc. 2011; 50: 116-154
- 89
McFarlane S.
The Wallstreet Journal, 2021 [cited 2021 Jul 9]. Shell Ordered by Dutch Court to Cut
Carbon Emissions. Available from: https://www.wsj.com/articles/shell-ordered-by-dutch-court-to-cut-carbon-emissions-11622038961
- 90 How industries can collaborate to put stakeholder capitalism into practice | World
Economic Forum [Internet]. [cited 2021 Jul 22]. Available from: https://www.weforum.org/agenda/2021/03/wip-how-industries-can-collaborate-to-drive-growth-and-put-stakeholder-capitalism-into-practice/
- 91
Brink C,
Drissen E,
Vollebergh H,
Wilting H.
Accounting for Environmental Damage by Material Production and use a comparison of
seven Western European countries Background Report Accounting for environmental damage
by material production and use. A comparison of seven Western European countries [Internet],
2020 [cited 2021 May 10]. Available from: www.pbl.nl/en
- 92
PBL.
Integrale Circulaire Economie Rapportage 2023, 2023
- 93 Rijkswaterstaat/Ministerie van Infrastructuur en Waterstaat. Biobased Kunststoffen; Actieplan: 2020
- 94 DEI+: Circular economy [Internet]. [cited 2023 Jun 27]. Available from: https://www.rvo.nl/subsidies-financiering/dei/dei-circulaire-economie
- 95
Netherlands Enterprise Agency (RVO).
International biobased and bioenergy project development tools Tools for Sustainable
Biobased Projects [Internet], 2014 [cited 2023 Jun 27]. Available from: www.globalbioenergy.org
- 96
COGEM.
Trendanalyse Biotechnologie 2023 TIJD VOOR Een Integrale Visie Maart 2023, 2023
- 97 Rathmann R, Szklo A, Schaeffer R. Land use competition for production of food and liquid biofuels: An analysis of the arguments in the current debate. Renewable Energy 2010; 35 (01) 14-22
- 98
Oecd.
The role of sustainability initiatives in mandatory due diligence Background note
on Regulatory Developments concerning Due Diligence for Responsible Business Conduct
2, 2022 [cited 2024 Oct 29]; Available from: https://mneguidelines.oecd.org/the-role-of-sustainability-initiatives-in-mandatory-due-diligence-note-for
- 99 Rosenbloom D, Markard J, Geels FW, Fuenfschilling L. Why carbon pricing is not sufficient to mitigate climate change – and how “sustainability transition policy” can help. Proc. Natl. Acad. Sci. U S A 2020; 117 (16) 8664-8668
- 100 Laibach N, Börner J, Bröring S. Exploring the future of the bioeconomy: An expert-based scoping study examining key enabling technology fields with potential to foster the transition toward a bio-based economy. Technol. Soc. 2019; 58
- 101
Schmidt Futures.
The U.S. Bioeconomy: Charting a Course for a Resilient and Competitive Future: A bioeconomy
strategy [Internet]. 2022 Apr [cited 2023 Jun 12]. Available from: https://www.schmidtfutures.com/wp-content/uploads/2023/05/Bioeconomy-Task-Force-Strategy-4.14.22-4.pdf
- 102 Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a
Sustainable, Safe, and Secure American Bioeconomy, The White House [Internet]. [cited
2023 Jun 12]. Available from: https://www.whitehouse.gov/briefing-room/presidential-actions/2022/09/12/executive-order-on-advancing-biotechnology-and-biomanufacturing-innovation-for-a-sustainable-safe-and-secure-american-bioeconomy/
- 103 Priority ten crucial technologies for economy, society and security, News item, Rijksoverheid.nl
[Internet]. [cited 2024 Oct 29]. Available from: https://www.rijksoverheid.nl/actueel/nieuws/2024/01/19/voorrang-tien-cruciale-technologieen-voor-economie-maatschappij-en-veiligheid
- 104 Ichim MC. The more favorable attitude of the citizens toward GMOs supports a new regulatory framework in the European Union. GM Crops Food 2021; 12 (01) 18-24 Available from: https://pubmed.ncbi.nlm.nih.gov/32787504/
- 105 Woźniak E, Tyczewska A, Twardowski T. A Shift Towards Biotechnology: Social Opinion in the EU. Trends Biotechnol. 2021; 39 (03) 214-218
- 106 Anyshchenko A. The Precautionary Principle in EU Regulation of GMOs: Socio-Economic Considerations and Ethical Implications of Biotechnology. J. Agric. Environ. Ethics 2019; 32 (5–6) 855-872 Available from: https://philpapers.org/rec/ANYTPP
- 107 Wehrs M, Tanjore D, Eng T, Lievense J, Pray TR, Mukhopadhyay A. Engineering Robust Production Microbes for Large-Scale Cultivation. Trends Microbiol. 2019; 27 (06) 524-537 Available from: https://pubmed.ncbi.nlm.nih.gov/30819548/
- 108
Bettenhausen C.
Evonik invests in rhamnolipid biosurfactants, 2022 Jan 19 [cited 2023 May 17]; Available
from: https://cen.acs.org/business/specialty-chemicals/Evonik-invests-rhamnolipid-biosurfactants/100/i3
- 109 Scientific Committee on Health and Environmental Risks SCHER. Scientific Committee on Emerging and Newly Identified Health Risks;, Scientific Committee on Consumer Safety. Preliminary Opinion on Synthetic Biology I Definition, 2014 pp 1-62
- 110 Implementation of the Transparency Regulation [Internet]. [cited 2023 Jun 7]. Available
from: https://food.ec.europa.eu/horizontal-topics/general-food-law/implementation-transparency-regulation_en
- 111 Horizon Europe [Internet]. [cited 2023 Jun 19]. Available from: https://research-and-innovation.ec.europa.eu/funding/funding-opportunities/funding-programmes-and-open-calls/horizon-europe_en
- 112 Recovery and Resilience Facility | European Commission [Internet]. [cited 2021 Jun
29]. Available from: https://ec.europa.eu/info/business-economy-euro/recovery-coronavirus/recovery-and-resilience-facility_en
- 113 Apply for MIA and VAMIL for entrepreneurs, RVO.nl, Public Service [Internet]. [cited
2021 Jun 29]. Available from: https://www.rvo.nl/subsidie-en-financieringswijzer/miavamil/ondernemers
- 114 WBSO: tax credit for research and development, RVO.nl [Internet]. [cited 2021 Jul
7]. Available from: https://english.rvo.nl/subsidies-programmes/wbso