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CC BY 4.0 · Horm Metab Res
DOI: 10.1055/a-2537-4692
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Asymmetric Dimethylarginine: A Never-Aging Story

Natalia Jarzebska
1   Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany
,
Stefan R. Bornstein
1   Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany
2   School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, United Kingdom of Great Britain and Northern Ireland
,
Sergey Tselmin
1   Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany
,
Ulrich Julius
1   Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany
,
Barbara Cellini
3   Department of Medicine and Surgery, University of Perugia, Perugia, Italy
,
Richard Siow
2   School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, United Kingdom of Great Britain and Northern Ireland
4   Ageing Research at King’s (ARK), King’s College London, London, United Kingdom of Great Britain and Northern Ireland
5   Department of Physiology, Anatomy and Genetics, Medical Sciences Division, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland
,
Mike Martin
6   Department of Psychology, University of Zurich, Zurich, Switzerland
7   Healthy Longevity Center, University of Zurich, Zurich, Switzerland
,
Rajeshwar P. Mookerjee
8   Institute of Liver and Digestive Health, University College London, London, United Kingdom of Great Britain and Northern Ireland
,
Arduino A. Mangoni
9   Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia
,
Norbert Weiss
1   Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany
,
Roman N. Rodionov 
1   Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany
9   Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia
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Erratum zu diesem Artikel:

Correction: Asymmetric Dimethylarginine: A Never-Aging StoryHorm Metab Res eFirst
DOI: 10.1055/a-2626-3601

Abstract

Human aging is intrinsically associated with the onset and the progression of several disease states causing significant disability and poor quality of life. Although such association was traditionally considered immutable, recent advances have led to a better understanding of several critical biochemical pathways involved in the aging process. This, in turn, has stimulated a significant body of research to investigate whether reprogramming these pathways could delay the progression of human ageing and/or prevent relevant disease states, ultimately favoring healthier aging process. Cellular senescence is regarded as the principal causative factor implicated in biological and pathophysiological processes involved in aging. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and an independent risk factor for several age-associated diseases. The selective extracorporeal removal of ADMA is emerging as a promising strategy to reduce the burden of age-associated disease states. This article discusses the current knowledge regarding the critical pathways involved in human aging and associated diseases and the possible role of ADMA as a target for therapies leading to healthier aging processes.

Keywords

asymmetric dimethylarginine - anti-aging therapy - therapeutic apheresis


Publikationsverlauf

Eingereicht: 02. Juli 2024

Angenommen nach Revision: 30. Dezember 2024

Artikel online veröffentlicht:
26. Mai 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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