Fibrinogen Replacement: A Questionable Dogma

Abstract

Management of hemostasis in the perioperative setting, in trauma or in acute care, has considerably changed over the last two decades. Viscoelastic testing and single-factor replacement therapies have become cornerstones of the respective clinical approaches. Here, we illuminate the basic theories for these approaches as well as the important evidence available. Both viscoelastic assays and single-factor replacements are important improvements; their use must be based on the strongest scientific evidence available.

Keywords

viscoelastic assays - factor concentrates - fibrinogen/fibrin - factor XIII/transglutaminases - resuscitation

Other Financial or Nonfinancial Interests

Director, HICC—Haemostasis in Critical Care GmbH.

Publikationsverlauf

Eingereicht: 11. November 2024

Angenommen: 09. Februar 2025

Artikel online veröffentlicht:
27. April 2025

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