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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd
DOI: 10.1055/a-2524-2474
GebFra Science
Original Article

Impact of SARS-CoV-2 Infection on the Course of Pregnancy and Birth After Assisted Reproduction

Article in several languages: English | deutsch
Violet Eckstein
1   Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
,
Katrin Glaß
1   Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
,
Jessica Schaar
1   Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
,
Pauline Wimberger
1   Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
,
Maren Goeckenjan 
1   Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
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Abstract

Introduction

The aim of this single center cohort study was to examine the possible effects of SARS-CoV-2 infection, especially the Omicron variant, on outcome of pregnancy and birth after infertility treatment with assisted reproduction.

Material and Methods

A total of 51 pregnancies and births after assisted reproduction were investigated in the period from 01/2022 to 12/2022 in a university fertility center with regards to SARS-CoV-2 infections and vaccination status. Eight multiple pregnancies were assessed separately. 20 women with singleton pregnancy had a confirmed SARS-CoV-2 infection in the six months prior to or during the pregnancy. This group was compared to 23 singleton pregnancies without SARS-CoV-2 infection or with infection had occurred more than six months before assisted reproduction.

Results

The comparison of single pregnancy with or without SARS-CoV-2 showed no differences considering age or body mass index. Complications of pregnancy such as preeclampsia, pregnancy-induced hypertension, placenta previa, placental insufficiency, and preterm labor were also comparable for both groups. There were no significant differences between the two groups with regards to gestational age at delivery, birth weight, birth mode, and APGAR scores. A comparison of the course of pregnancy in women with and women without basic immunization also showed no significant differences.

Conclusion

In the study period of 2022, infection with SARS-CoV-2, in most cases with the Omicron variant, during or up to six months prior to a pregnancy following assisted reproduction did not significantly affect the risk of maternal and fetal complications of pregnancy from the 2nd trimester of pregnancy or the fetoneonatal outcome.

Keywords

preterm birth - viral infection - coronavirus

Supplementary Material



Publication History

Received: 27 September 2024

Accepted after revision: 07 December 2024

Article published online:
19 May 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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