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CC BY-NC-ND 4.0 · Thromb Haemost 2025; 125(09): 923-932
DOI: 10.1055/a-2508-1112
Meeting Report

Primary versus Secondary Immune Thrombocytopenia (ITP): A Meeting Report from the 2023 McMaster ITP Summit

Dimpy Modi 
1   Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada
,
Saifur R. Chowdhury
1   Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada
2   Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada
,
Syed Mahamad 
1   Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada
,
Hayley Modi
1   Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada
3   Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
,
Douglas B. Cines
4   Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
,
Cindy E. Neunert
5   Columbia University Irving Medical Center, New York, New York, United States
,
Hanny Al-Samkari 
6   Division of Hematology Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, United States
,
Nichola Cooper
7   Hammersmith Hospital, Imperial College, London, United Kingdom
,
Guillaume Moulis
8   Department of Internal Medicine, Toulouse University Hospital, Toulouse, France
,
Charlotte Cunningham-Rundles
9   Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States
,
Howard A. Liebman
10   University of Southern California-Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States
,
James B. Bussel
11   Platelet Research & Treatment Program Weill, Cornell Medicine, New York, United States
,
Vicky R. Breakey
12   McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada
,
Ishac Nazy
1   Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada
3   Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
13   Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
,
Donald M. Arnold
1   Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada
13   Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
› Institutsangaben
Funding Funding for the McMaster ITP Summit was provided by: Alpine Immune Sciences Inc., Swedish Orphan Biovitrum, Amgen Canada, Argenx, Sanofi, Pfizer and Medison. Funding from these sources was used to plan and host the Summit, and for honoraria for the presenters. The funders had no role in the planning of the event or in the preparation of the article.
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Abstract

The McMaster Immune Thrombocytopenia (ITP) Summit, held on October 27, 2023, was an educational seminar from leading experts in immune thrombocytopenia and related disorders geared toward hematologists, internists, immunologists, and clinical and translational scientists. The focus of the Summit was to review the mechanisms, diagnosis, and treatment of primary versus secondary ITP. Specific objectives were to describe the unique features of secondary ITP, and to review its mechanisms in the context of autoimmune disease and infection. The key messages in this Summit were: (1) ITP is a heterogeneous disease, and genetic and immunologic insights may help classify patient subtypes; (2) exploring the autoimmune mechanisms and their association with hypogammaglobulinemia in patients with secondary ITP could improve our understanding of ITP and its subtypes; (3) investigating the mechanisms of ITP in the context of infections caused by viruses such as CMV, HIV, dengue, and hepatitis C, or bacteria such as H. pylori, or vaccinations could provide insight into the causes of ITP. A better understanding of secondary ITP could help elucidate the pathogenesis of ITP.

Keywords

bleeding - immune thrombocytopenia - platelet - immunology - infection

Authors' Contribution

All authors contributed to writing the article, providing critical feedback, and helping shape the research described in the article. The section Secondary ITP was written by D.C., the section Diagnosis of Primary versus Secondary ITP was written by C.N., the section Novel Targets for ITP Treatment: Informing Disease Mechanism was written by H.A., the section ITP in the Context of Autoimmune Disease was written by N.C., the section ITP and SLE was written by G.M., the section ITP and Primary Antibody Defects was written by C.C., the section ITP and Infection was written by J.B., the section ITP Secondary to HIV and HCV was written by H.L., and the section Vaccine-related ITP was written by V.B. D.M. took the lead in editing the article, with support from S.R.C., S.M., and H.M. D.A. supervised the project.




Publikationsverlauf

Eingereicht: 07. November 2024

Angenommen: 18. Dezember 2024

Accepted Manuscript online:
24. Dezember 2024

Artikel online veröffentlicht:
20. Januar 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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