HPV-associated Sinonasal Squamous Cell Carcinoma

Abstract

Human papillomavirus (HPV)-associated sinonasal squamous cell carcinoma (SNSCC) (HPV+ SNSCC) is a recently recognized entity that accounts for up to one-third of SNSCC. Although at present these cancers are not routinely tested for HPV, the incidence is increasing and HPV+ SNSCC is associated with superior survival outcomes compared with HPV− SNSCC. Here, we present the case of a patient with HPV+ SNSCC treated with endoscopic resection followed by postoperative radiation and review the literature summarizing epidemiology and management of this disease, with emphasis on the importance of HPV testing in SNSCC.

Keywords

human papillomavirus - squamous cell carcinoma - sinonasal - endoscopic

Publikationsverlauf

Eingereicht: 21. Oktober 2024

Angenommen: 24. November 2024

Accepted Manuscript online:
05. Dezember 2024

Artikel online veröffentlicht:
07. Januar 2025

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