New Constituents from Zanthoxylum rhoifolium

Abstract

The phytochemical study of Zanthoxylum rhoifolium apolar and medium polarity stem bark and leaf extracts afforded 29 compounds, including three new sesquiterpenes (1 – 3) and one new α-ionone glycoside (4). All compounds were characterized by means of 1D and 2D NMR and HRESIMS data. Furthermore, a precise structural analysis was performed, employing a combined density functional theory (DFT)/NMR approach to elucidate the compounds configurations. The crude extracts were then tested against a panel of gram-positive and gram-negative bacteria by broth dilution methods to determine their minimal inhibitory concentration. In these experimental conditions, no interesting antimicrobial activity was observed.

Keywords

Zanthoxylum rhoifolium - Rutaceae - sesquiterpenes - α-ionone - DFT/NMR - antibacterial

Publication History

Received: 27 June 2024

Accepted after revision: 25 November 2024

Accepted Manuscript online:
25 November 2024

Article published online:
13 January 2025

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