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DOI: 10.1055/a-2421-7430
Solvent-Free Approaches for the Synthesis of Lophine Derivatives

Abstract
Solvent-free synthesis comes with many advantages such as cost reduction, waste reduction, ease of operation, sustainability, environmentally benign operations, etc. These benefits have prompted many chemists to develop new protocols for solvent-free synthesis of various interesting chemical compounds. One such class of compounds is 2,4,5-triarylimidazoles, commonly known as lophines due to their applications in materials science, chemo- and bio-sensors, and pharmacology. This article focuses on solvent-free synthesis of lophine derivatives via different protocols, including the use of inorganic-, organic-, and biocatalysts; solid-supported catalysts; microwave-mediated heating; and grinding.
Keywords
Lophine - Triaryl imidazoles - Imidazoles - Solvent-free - Neat - Sustainable chemistry - Green chemistry - Multicomponent reactionsPublication History
Received: 18 July 2024
Accepted after revision: 20 September 2024
Accepted Manuscript online:
27 September 2024
Article published online:
11 November 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
Shiv R. Desai, Sachin G. Modha. Solvent-Free Approaches for the Synthesis of Lophine Derivatives. Sustainability & Circularity NOW 2024; 01: a24217430.
DOI: 10.1055/a-2421-7430
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