RSS-Feed abonnieren
DOI: 10.1055/a-2414-7696
Necrotizing Fasciitis Post-Cesarean Section Leading to Transabdominal Hysterectomy
Abstract
Necrotizing fasciitis (NF) is a rare but life-threatening disease characterized by rapidly spreading inflammation and subsequent necrosis of the fascial planes and surrounding tissues. Limited literature has described NF as involving an adjacent solid organ beyond fascial planes that has required its removal. We present a case of a 25-year-old white female who underwent a cesarean section and subsequently developed NF involving her uterus and abdominal wall that necessitated a total abdominal hysterectomy, serial surgical debridement of necrotic tissue, and wound vacuum assisted closure (VAC) placement. Her pathology report described her uterus infiltrated by polybacteria, confirming a diagnosis of NF. Despite NF's progressive nature and potential lethality, NF can be challenging to diagnose clinically due to a lack of pathognomonic signs and symptoms. However, early detection of NF with the aid of Laboratory Risk Indicator for Necrotizing Fasciitis score calculation using laboratory values such as white blood cell count, hemoglobin, sodium, glucose, serum creatinine, and C-reactive protein is critical for optimal patient outcomes. A multidisciplinary team approach is vital in treating these patients to debride necrotizing tissue and control the potential sequelae from the infection, particularly for postpartum patients.
Keywords
necrotizing fasciitis (NF) - pregnancy - necrotizing soft tissue infection - hysterectomy - postpartumPublikationsverlauf
Eingereicht: 16. Mai 2024
Angenommen: 04. August 2024
Accepted Manuscript online:
13. September 2024
Artikel online veröffentlicht:
30. September 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 O'Loughlin RE, Roberson A, Cieslak PR. et al; Active Bacterial Core Surveillance Team. The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004. Clin Infect Dis 2007; 45 (07) 853-862
- 2 Fasciitis N. JAAOS - Journal of the American Academy of Orthopaedic Surgeons. Accessed February 3, 2024 at: https://journals.lww.com/jaaos/fulltext/2009/03000/necrotizing_fasciitis.6.aspx
- 3 Mulla ZD. Treatment options in the management of necrotising fasciitis caused by group A Streptococcus. Expert Opin Pharmacother 2004; 5 (08) 1695-1700
- 4 Immunocompromised Status in Patients With Necrotizing Soft-Tissue Infection | Oncology | JAMA Surgery | JAMA Network. Accessed February 3, 2024 at: https://jamanetwork-com.proxy.library.vanderbilt.edu/journals/jamasurgery/fullarticle/1686088
- 5 Api M, Aytan H, Adlguzel C, Nazik H, Narin R, Kale A. Necrotizing fasciitis following hysterectomy: a case report. J Clin Gynecol Obstet 2012; 1 (2–3): 46-48
- 6 Zhang M, Chen L, Chi K, Xu L, Li Y. Necrotizing fasciitis complicated with multiple organ dysfunction syndrome after breast augmentation with fat from the waist and lower extremities: a case report. J Int Med Res 2020; 48 (07) 300060520937623
- 7 Smuszkiewicz P, Trojanowska I, Tomczak H. Late diagnosed necrotizing fasciitis as a cause of multiorgan dysfunction syndrome: a case report. Cases J 2008; 1 (01) 125
- 8 Light TD, Choi KC, Thomsen TA. et al. Long-term outcomes of patients with necrotizing fasciitis. J Burn Care Res 2010; 31 (01) 93-99
- 9 Wong CH, Khin LW, Heng KS, Tan KC, Low CO. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med 2004; 32 (07) 1535-1541
- 10 Bechar J, Sepehripour S, Hardwicke J, Filobbos G. Laboratory risk indicator for necrotising fasciitis (LRINEC) score for the assessment of early necrotising fasciitis: a systematic review of the literature. Ann R Coll Surg Engl 2017; 99 (05) 341-346
- 11 Hua J, Friedlander P. Cervical necrotizing fasciitis, diagnosis and treatment of a rare life-threatening infection. Ear Nose Throat J 2023; 102 (03) NP109-NP113
- 12 Francis KR, Lamaute HR, Davis JM, Pizzi WF. Implications of risk factors in necrotizing fasciitis. Am Surg 1993; 59 (05) 304-308
- 13 Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 199: use of prophylactic antibiotics in labor and delivery. Obstet Gynecol 2018; 132 (03) e103-e119
- 14 Tita ATN, Szychowski JM, Boggess K. et al; C/SOAP Trial Consortium. Adjunctive azithromycin prophylaxis for cesarean delivery. N Engl J Med 2016; 375 (13) 1231-1241
- 15 Peetermans M, de Prost N, Eckmann C, Norrby-Teglund A, Skrede S, De Waele JJ. Necrotizing skin and soft-tissue infections in the intensive care unit. Clin Microbiol Infect 2020; 26 (01) 8-17
- 16 Abdurrazaq TO, Ibikunle AA, Braimah RO. Cervical necrotizing fasciitis: a potentially fatal disease with varied etiology. Ann Med Health Sci Res 2016; 6 (04) 251-256
- 17 Aronoff DM, Bloch KC. Assessing the relationship between the use of nonsteroidal antiinflammatory drugs and necrotizing fasciitis caused by group A streptococcus. Medicine (Baltimore) 2003; 82 (04) 225-235
- 18 Bryant AE, Bayer CR, Aldape MJ, Stevens DL. The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections. Curr Opin Infect Dis 2015; 28 (03) 231-239
- 19 Weng TC, Chen CC, Toh HS, Tang HJ. Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice. J Microbiol Immunol Infect 2011; 44 (06) 418-423
- 20 Tarricone A, Mata K, Gee A. et al. A systematic review and meta-analysis of the effectiveness of LRINEC score for predicting upper and lower extremity necrotizing fasciitis. J Foot Ankle Surg 2022; 61 (02) 384-389
- 21 Oppegaard O, Rath E. Treatment of Necrotizing Soft Tissue Infections: Antibiotics. Adv Exp Med Biol 2020; 1294: 87-103
- 22 Hsiao CT, Chang CP, Huang TY, Chen YC, Fann WC. Prospective validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for necrotizing fasciitis of the extremities. PLoS One 2020; 15 (01) e0227748
- 23 Ioannidis O, Kitsikosta L, Tatsis D. et al. Fournier's gangrene: lessons learned from multimodal and multidisciplinary management of perineal necrotizing fasciitis. Front Surg 2017; 4: 36
- 24 Chennamsetty A, Khourdaji I, Burks F, Killinger KA. Contemporary diagnosis and management of Fournier's gangrene. Ther Adv Urol 2015; 7 (04) 203-215
- 25 Misiakos EP, Bagias G, Patapis P, Sotiropoulos D, Kanavidis P, Machairas A. Current concepts in the management of necrotizing fasciitis. Front Surg 2014; 1: 36
- 26 van Stigt SFL, Schrooten TKJ, Knubben M, Tan ECTH. Impact of severe necrotizing fasciitis on quality of life in the Netherlands. Eur J Trauma Emerg Surg 2022; 48 (06) 4805-4811