Abstract
The metal hydride catalyzed alkene hydroalkylation enables efficient alkyl–alkyl coupling,
yielding structurally diverse chiral organic compounds. However, the control of stereochemical
selectivity in alkene hydroalkylation still heavily relies on the assistance of substrate
Lewis basic functional groups or polar heteroatom functional groups. We have recently
developed a cobalt hydride catalytic system and established a paradigm of enantioselective
control assisted by C–H···π noncovalent interactions. This approach enables the asymmetric
hydroalkylation of 1,1-disubstituted styrenes, thereby circumventing the limitations
imposed by substrate heteroatom functional groups.
1 Introduction
2 Reaction Development
3 Synthetic Applications
4 Mechanistic Investigation
5 Conclusion and Future Outlook
Key words
cobalt catalysis - asymmetric catalysis - alkyl–alkyl coupling - alkene hydroalkylation
- 1,1-disubstituted styrenes - C–H···π interaction
