This report outlines an intramolecular oxidative annulation process involving N-substituted
o-amino phenylacetylene, performed under electrochemical conditions, which yields substituted
quinoline in an undivided cell at room temperature. The reaction features mild conditions,
requiring neither external oxidants nor metals, and achieves yields that range from
good to excellent. Moreover, the synthetic potential of quinoline has been demonstrated
resulting in the synthesis of substituted polycyclic isoindolinone and (aza-)isoindolinone
compounds.
Key words
oxidative annulation - intramolecular electrochemical synthesis - aromatic enamine
- substituted quinoline - polycyclic compounds
