Dedicated to Prof. Brindaban C. Ranu on the occasion of his 75th birth anniversary
Abstract
The impetuous development of the pharmaceutical industry and material science stimulates
the search for new synthetic approaches and new methods for the synthesis and functionalization
of aza-heterocycles; these are some of the key objectives of modern organic chemistry.
As a result, an advanced method towards the synthesis of functionalized N-heterocycles
that circumvents the limitations associated with traditional methods needs to be devised.
In recent decades, rearrangement/reorganization reactions have emerged as a powerful
tool for the efficient synthesis of the aza-heterocycle. In this illustration, we
summarize some our recent efforts in the development of few complex aza-heterocyclic
cores.
1 Introduction
2 Skeletal Rearrangement of Small Heterocycles via Domino Ring-Opening and Ring-Closing
(DROC) Strategy
3 Ru(II)-Catalyzed Skeletal Rearrangement of the Quinazoline Ring
4 Lewis Acid Catalyzed Skeletal Rearrangement of Furans to Indolizine Cores
5 Skeletal Rearrangement of Donor–Acceptor Cyclopropanes via Domino Ring-Opening
and Ring-Closing (DROC) Strategy
6 Lewis Acid Mediated Skeletal Rearrangement of Donor–Acceptor Spirocyclopropylpyrazolones
7 Skeletal Rearrangement through Ring Distortion Strategy
8 Conclusion
Key words
reorganization approach - Brønsted acid - Lewis acid - 1
H-azidirine - 2-pyridone - indolizine nucleus
