Abstract
The liver has the great ability to regenerate after partial resection or injury, and
the mechanisms underlying liver regeneration have been extensively investigated. Interestingly,
acute liver injuries triggered by various etiologies are associated with the formation
of necrotic lesions, and such necrotic lesions are also rapidly resolved. However,
how necrotic liver lesions are repaired has not been carefully investigated until
recently. In this review, we briefly summarize the spatiotemporal process of necrotic
liver lesion resolution in several liver injury models including immune-mediated liver
injury and drug-induced liver injury. The roles of liver nonparenchymal cells and
infiltrating immune cells in controlling necrotic liver lesion resolution are discussed,
which may help identify potential therapies for acute liver injury and failure.
Keywords
liver necrotic lesion - acute liver injury - macrophages - concanavalin A (ConA) -
acetaminophen (APAP)
