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Horm Metab Res
DOI: 10.1055/a-2356-8223
Original Article: Endocrine Care

Evaluation of the Malignancy Risk in Nodules Expanding the Thyroid Gland Capsule

Ismail Emre Arslan
1   Endocrinology and Metabolism, Ministry of Health Ankara Etlik City Hospital, Ankara, Turkey (Ringgold ID: RIN649432)
,
Hayri Bostan 
2   Endocrinology and Metabolism, Ministry of Health Canakkale Mehmet Akif Ersoy State Hospital, Canakkale, Turkey (Ringgold ID: RIN653177)
,
Sema Hepşen 
1   Endocrinology and Metabolism, Ministry of Health Ankara Etlik City Hospital, Ankara, Turkey (Ringgold ID: RIN649432)
,
Pinar Akhanli
3   Endocrinology and Metabolism, Erzurum Bölge Eğitim ve Araştırma Hastanesi, Erzurum, Turkey (Ringgold ID: RIN215289)
,
Muhammed Erkam Sencar
4   Endocrinology and Metabolism, Medicana International Ankara Hospital, Ankara, Turkey (Ringgold ID: RIN432262)
,
Erman Cakal
1   Endocrinology and Metabolism, Ministry of Health Ankara Etlik City Hospital, Ankara, Turkey (Ringgold ID: RIN649432)
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Abstract

There has been an increase in the diagnosis of thyroid nodules in recent years. In addition to the well-known criteria, features that are likely to increase the risk of malignancy are in the research process. In this study, we aimed to evaluate the malignant potential of nodules that expand the thyroid capsule ultrasonographically. A total of 109 patients with thyroid capsule-expanding nodules and 288 patients with non-expanding nodules were included in the study. Demographical data, ultrasonography features, and cytology results were noted, and histopathological findings were determined in operated patients. While malignant cytology was detected in 5.5% of capsule-expanding nodules in FNAB results, this rate was 0.7% in the non-capsule expanding group (p<0.001). According to the histopathological results, the incidence of malignancy was 15.6% in the capsule-expanding nodule group, while it was 3.1% in the other group (p=0.001). As a result of logistic regression analysis, it was determined that the risk of malignancy increased by 4.44-fold (95% CI 1.4–13.8, p=0.01) in patients with capsule-expanding nodules. Other features that increased the risk of malignancy were hypoechogenicity, microcalcification, and irregular margin presence. In this study, we found that the risk of malignancy increased in nodules expanding the thyroid capsule. Based on the increasing study data on this subject, monitoring thyroid capsule expansion in nodules may take its place among the criteria for malignancy in future evaluations.

Keywords

thyroid carcinoma - capsule expansion - thyroid ultrasonography - malignancy risk


Publikationsverlauf

Eingereicht: 11. März 2024

Angenommen nach Revision: 27. Juni 2024

Accepted Manuscript online:
28. Juni 2024

Artikel online veröffentlicht:
26. Juli 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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