Anästhesiologie im Rhythmus

Wie beeinflusst unsere innere Uhr die Anästhesie und den Heilungsverlauf? Zirkadiane Rhythmen spielen eine zentrale Rolle für Gesundheit und Genesung. Das Topthema der aktuellen Ausgabe der AINS beschäftigt sich damit, wie chronobiologische Erkenntnisse die perioperative Versorgung verbessern und neue Wege für personalisierte Therapien eröffnen können.

Publikationsverlauf

Artikel online veröffentlicht:
28. Oktober 2025

• Literatur

• 1 Czeisler CA. The effect of light on the human circadian pacemaker. Ciba Found Symp 1995; 183: 254-290
• 2 Lewis P, Korf HW, Kuffer L. et al. Exercise time cues (zeitgebers) for human circadian systems can foster health and improve performance: a systematic review. BMJ Open Sport Exerc Med 2018; 4: e000443
• 3 Lewis P, Oster H, Korf HW. et al. Food as a circadian time cue – evidence from human studies. Nat Rev Endocrinol 2020; 16: 213-223
• 4 Kramer A, Lange T, Spies C. et al. Foundations of circadian medicine. PLOS Biology 2022; 20: e3001567
• 5 Roenneberg T, Foster RG, Klerman EB. The circadian system, sleep, and the health/disease balance: a conceptual review. J Sleep Res 2022; 31: e13621
• 6 Koch CE, Leinweber B, Drengberg BC. et al. Interaction between circadian rhythms and stress. Neurobiol Stress 2017; 6: 57-67
• 7 Gao L, Li P, Zheng X. et al. Circadian Rest–Activity Rhythms, Delirium Risk, and Progression to Dementia. Ann Neurol 2023; 93: 1145-1157
• 8 Spies C, Piazena H, Deja M. et al. Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study. Crit Care Med 2024; 52: e182
• 9 Jafarifiroozabadi R, Joseph A, Bridges W. et al. The impact of daylight and window views on length of stay among patients with heart disease: A retrospective study in a cardiac intensive care unit. J Intensive Med 2023; 3: 155-164
• 10 Lee HJ, Bae E, Lee HY. et al. Association of natural light exposure and delirium according to the presence or absence of windows in the intensive care unit. Acute Crit Care 2021; 36: 332-341
• 11 Locihová H, Axmann K, Padyšáková H. et al. Effect of the use of earplugs and eye mask on the quality of sleep in intensive care patients: a systematic review. J Sleep Res 2018; 27: e12607
• 12 Bonatto FS, Pilz LK, Borges RB. et al. Daylight exposure and mood in real life: Direct association and mediating role of sleep and routine regularity. Chronobiol Int 2024; 41: 1128-1141
• 13 de Sá Couto-Pereira N, Nexha A, Boff Borges R. et al. Routine regularity during a global pandemic: Impact on mental health outcomes and influence of chronotype. Chronobiol Int 2024; 41: 456-472
• 14 Rabiee A, Nikayin S, Hashem MD. et al. Depressive symptoms after critical illness: a systematic review and meta-analysis. Crit Care Med 2016; 44: 1744-1753
• 15 Buttgereit F, Doering G, Schaeffler A. et al. Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet 2008; 371: 205-214
• 16 Karaboué A, Innominato PF, Wreglesworth NI. et al. Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?. Br J Cancer 2024; 131: 783-796
• 17 Chassard D, Bruguerolle B. Chronobiology and anesthesia. Anesthesiology 2004; 100: 413-427
• 18 Meewisse AJG, Gribnau A, Thiessen SE. et al. Effect of time of day on outcomes in elective surgery: a systematic review. Anaesthesia 2024; 79: 1325-1334
• 19 Kork F, Spies C, Conrad T. et al. Associations of postoperative mortality with the time of day, week and year. Anaesthesia 2018; 73: 711-718
• 20 Poulsen RC, Warman GR, Sleigh J. et al. How does general anaesthesia affect the circadian clock?. Sleep Med Rev 2018; 37: 35-44
• 21 Montaigne D, Marechal X, Modine T. et al. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study. Lancet 2018; 391: 59-69
• 22 Wittenbrink N, Ananthasubramaniam B, Münch M. et al. High-accuracy determination of internal circadian time from a single blood sample. J Clin Invest 2018; 128: 3826-3839
• 23 Lachmann G, Ananthasubramaniam B, Wünsch VA. et al. Circadian rhythms in septic shock patients. Ann Intensive Care 2021; 11: 64
• 24 Maas MB, Iwanaszko M, Lizza BD. et al. Circadian Gene Expression Rhythms during Critical Illness. Crit Care Med 2020; 48: e1294-e1299