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CC BY-NC-ND 4.0 · Exp Clin Endocrinol Diabetes 2024; 132(10): 562-569
DOI: 10.1055/a-2348-4468
Article

NT-pro-BNP Level is Related to Left Ventricular Remodeling in Patients With Primary Aldosteronism

Tao Wu‡
1   Department of Radiology, West China Hospital, Sichuan University
,
Chenxiao Xu‡
2   Department of Endocrinology and Metabolism, West China Hospital, Sichuan University
,
Lu Tang
1   Department of Radiology, West China Hospital, Sichuan University
,
Xi Wu
3   North Sichuan Medical College
,
Pengfei Peng
1   Department of Radiology, West China Hospital, Sichuan University
,
Xun Yue
3   North Sichuan Medical College
,
Wei Cheng
1   Department of Radiology, West China Hospital, Sichuan University
,
Shuai He
1   Department of Radiology, West China Hospital, Sichuan University
,
Lei Li
1   Department of Radiology, West China Hospital, Sichuan University
,
Yucheng Chen
4   Cardiology Division, West China Hospital, Sichuan University
,
Yan Ren
2   Department of Endocrinology and Metabolism, West China Hospital, Sichuan University
,
Jiayu Sun
1   Department of Radiology, West China Hospital, Sichuan University
› Author Affiliations Funding This work was supported by grants from the Key R & D Projects in Sichuan Province (No. 2020YFS0123) and 1·3·5 Project for Disciplines of Excellence–Clinical Research Incubation Project (2018HXFH009).
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Abstract

Aims To assess the relationship between the left ventricular remodeling parameters of cardiac magnetic resonance and NT-pro-BNP in patients with primary aldosteronism (PA).

Methods Seventy-four PA and 39 essential hypertension patients were prospectively recruited and underwent cardiac magnetic resonance. Plasma NT-pro-BNP was measured before patients underwent cardiac magnetic resonance. Left ventricular remodeling parameters were defined as left ventricular function parameters, T1 mapping parameters, and strain parameters. Differences in continuous variables between two groups were analyzed using Student’s t-test or Mann–Whitney U test. Differences in categorical variables between two groups were analyzed by chi-squared test. Spearman’s correlation and linear regression were used to analyze the relationships between left ventricular remodeling parameters and plasma NT-Pro-BNP level. P<0.05 was considered as statistically significant.

Results Patients with PA demonstrated higher NT-pro-BNP [86.0 (49.5, 145.5) vs. 45.0 (28.5, 73.5) pg/mL, P=0.001] and Native T1 (1227±41 vs. 1206±43 ms, P=0.015) level than essential hypertension patients. Compared to patients with normal NT-pro-BNP levels, those with abnormal levels demonstrated different left ventricular remodeling parameters. NT-pro-BNP level was independently related to native T1 (β=0.316, P=0.006), extracellular volume (β=0.419, P<0.001), short-axis global circumferential strain (β=0.429, P<0.001), four-chamber global longitudinal strain (β=0.332, P=0.002), and four-chamber global radial strain (β=-0.334, P=0.004) in patients after adjusting for baseline characteristics.

Conclusions NT-pro-BNP level was related to left ventricular remodeling parameters derived from cardiac magnetic resonance in patients with PA. This result implies that clinicians should pay attention to NT-pro-BNP assessment in patients with PA in routine clinical assessment.

Keywords

primary aldosteronism - cardiac magnetic resonance imaging - NT-pro-BNP - left ventricular remodeling

Zusätzliches Material



Publication History

Received: 08 March 2024
Received: 01 May 2024

Accepted: 03 June 2024

Article published online:
02 September 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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