Antacida in der Tiermedizin – ist ein komplementärer Ansatz möglich?

Antacida werden sowohl von Haltern als auch Tierärzten in der Kleintierpraxis immer wieder routinemäßig therapeutisch oder prophylaktisch eingesetzt. Nun stellt sich die Frage, ob diese Vorgehensweise sinnvoll ist? Oder ist sie gar nachteilig, und welche Alternativen oder passendere therapeutische bzw. prophylaktische Ansätze gibt es?

• Literatur

• 1 Neiger R, Salavati-Schmitz S. Magenerkrankungen. In: Kohn, Praktikum der Hundeklinik, 7. Aufl. Georg Thieme Verlag KG; 2017. S. 744-758
• 2 Wolffram S. Funktionen des einhöhligen Magens. In: Breves et al. Physiologie der Haustiere. Georg Thieme Verlag KG; 2022. S. 427-433
• 3 Kargman S, Charlesion S, Cartwright M, Frank J, Riendeaw D, Mancini J, Evans J, O’Neil G. Characterization of prostaglandinG/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology 1993; 111: 445-454
• 4 Tanaka A, Hatazawa R, Takahira Y, Izumi N, Filaretova L, Takeuchi K. Preconditioning stress prevents cold restraint stress-induced gastric lesions in rats: Roles of COX-1, COX-2, and PLA 2. Digestive diseases and sciences 2007; 52: 478-487
• 5 Parrah JD, Moulvi BA, Gazi MA, Makhdoomi DM, Athar H, Dar S, Mir AQ. Gastric ulceration in dog: A review. Vet world 2013; 6: 449-454
• 6 Royer CM, Willard M, Williamson K, Steiner JM, Williams DA, David M. Exercise stress, intestinal permeability and gastric ulceration in racing Alaskan sled dogs. Equine and Comparative Exercise. Physiology 2005; 2: 53-59
• 7 Marks SL, Kook PH, Papich MG, Tolbert MK, Willard MD. ACVIM consensus statement: support for rational administration of gastrointestinal protectants to dogs and cats. Journal of veterinary internal medicine 2018; 32: 1823-1840
• 8 Betari N, Sahlholm K, Morató X, Godoy-Marín H, Jáuregui O, Teigen K, Ciruela F, Haavik J. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole – In Vitro and In Vivo Investigations. Frontiers in Pharmacology 2020; 11
• 9 Lione A. Aluminum intake from non-prescription drugs and sucralfate. General Pharmacology: The Vascular System 1985; 16: 223-228
• 10 Brendieck-Worm C, Melzig MF. Phytotherapie in der Tiermedizin, 2. Auflage. Georg Thieme Verlag; 2021
• 11 Bezerra SB, Leal LKAM, Nogueira NAP, Campos AR. Bisabolol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide, and K+ ATP channels. Journal of medicinal food 2009; 12: 1403-1406
• 12 Khayyal MT, El-Ghazaly MA, Kenawy SA, Seif-El-Nasr M, Mahran LG, Kafafi YA, Okpanyi SN. Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination. Arzneimittelforschung 2001; 51: 545-553
• 13 Szelenyi I, Isaac O, Thiemer K. Pharmacological experiments with compounds of chamomile. III. Experimental studies of the ulcerprotective effect of chamomile (author's transl). Planta medica 1979; 35: 218-227
• 14 Guslandi M. Ulcer-healing drugs and endogenous prostaglandins. International journal of clinical pharmacology, therapy, and toxicology 1985; 23: 398-402
• 15 Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MBPP. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytother Res 2018; 32: 2323-2339
• 16 Nazari S, Rameshrad M, Hosseinzadeh H. Toxicological effects of Glycyrrhiza glabra (licorice): a review. Phytotherapy research 2017; 31: 1635-1650
• 17 Gorbacheva AV, Aksinenko SG, Zelenskaja KL, Nesterova YV, Pashinskij VG. Anti-ulcerogenic characteristics of Filipendula ulmaria (L.) Maxim. Rastitelnye Resursy. Nauka, Sankt-Petersburg. 2002. 38. 114-119
• 18 Tovey FI, Bardhan KD, Hobsley M. Dietary Phosphilipids and Sterols Protective against Peptic Ulceration. Phytotherapy Research 2013; 27: 1265-1269
• 19 Wang HE, Chang CH, Ker YB, Peng CC, Chen KC, Peng RY. Fermented soybean liquid alleviated peptic ulcer through the destruction of acidic proton pump rather than suppression of urease of Helicobacter pylori: a kinetic analysis. Journal of agricultural and food chemistry 2011; 59: 6730-6739
• 20 Mikawa S, Matsuda A, Kamemori Y, Asanuma S, Kitagawa H. Enhancement of natural killer cell activity by oral administration of a fermented soybean product in dogs. Open Veterinary Journal 2021; 11: 394-400
• 21 Liu L, Chen X, Hao L, Zhang G, Jin Z, Li C, Yang Y, Rao J, Chen B. Traditional fermented soybean products: processing, flavor formation, nutritional and biological activities. Critical Reviews in Food Science and Nutrition 2020; 62: 1-19
• 22 Arora A, Sharma MP. Use of banana in non-ulcer dyspepsia. The Lancet 1990; 335: 612-613
• 23 Isah U, Abdulkadir B, Raubilu IA, Ahmad MA, Kabir K. An Overview on the Healing Potentials of Musa sapientm (Banana) in the Treatment of Peptic Ulcer Disease. UMYU. Journal of Microbiology Research (UJMR) 2019; 4: 31-35
• 24 Liaqat H, Parveen A, Kim SY. Neuroprotective Natural Products’ Regulatory Effects on Depression via Gut–Brain Axis Targeting Tryptophan. Nutrients 2022; 14: 3270
• 25 Konturek PC, Burnat G, Brzozowski T, Zopf Y, Konturek SJ. Tryptophan free diet delays healing of chronic gastric ulcers in rat. J Physiol Pharmacol 2008; 59: 53-65
• 26 Min SH, Gobbi G, Posa L. Melatonin and its Receptors. McGill Science Undergraduate Research Journal 2017; 12: 38-43