Download PDF
CC BY 4.0 · Endosc Int Open
DOI: 10.1055/a-2330-9803
Original article

A new through-the-scope clip with anchor prongs is safe and successful for a variety of endoscopic uses: a case series (with videos)

John J. Guardiola 
1   Divsion of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, United States (Ringgold ID: RIN12250)
,
Douglas K. Rex
2   Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, United States (Ringgold ID: RIN12250)
,
Christopher C. Thompson 
3   Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, United States (Ringgold ID: RIN1861)
,
Jeffrey Mosko
4   Gastroenterology, St Michael's Hospital, Toronto, Canada (Ringgold ID: RIN10071)
,
Marvin Ryou
5   Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, United States (Ringgold ID: RIN1861)
,
Joyce Peetermans
6   Endoscopy, Boston Scientific Corp, Marlborough, United States (Ringgold ID: RIN5724)
,
Matthew J Rousseau
7   Endoscopy, Boston Scientific Corp, Saint Paul, United States (Ringgold ID: RIN5724)
,
Daniel von Renteln
8   Gastroenterology, University of Montreal, Montreal, Canada (Ringgold ID: RIN5622)
› Author AffiliationsSupported by: Boston Scientific Corporation
Supported by: Fonds de Recherche du Québec Santé Career Award

Clinical Trial: Registration number (trial ID): NCT05653843, Trial registry: ClinicalTrials.gov (http://www.clinicaltrials.gov/), Type of Study: Prospective, Multi-Center
› Further Information
Also available at
  PDF Download

Background & Aims: Endoscopic through-the-scope clips (TTSC) are used for hemostasis and closure. We documented the performance of a new TTSC with anchor prongs. Methods: We conducted a prospective case series of the new TTSC in 50 patients with an indication for endoscopic clipping at 3 hospitals in the USA and Canada. Patients were followed for 30 days after index procedure. Outcomes included defect closure and rate of serious adverse events (SAEs) related to the device or procedure. Results: Fifty patients had 56 clipping procedures. Thirty-four procedures were clipping after EMR in colon (33) or stomach (1), 16 after polypectomy, 2 for hemostasis of active bleeding, and 1 each for fistula closure, post-POEM mucosal closure, or anchoring a feeding tube. Complete defect closure was achieved in 32/33 colon EMR defects and 21/22 other defects. All clips were placed per labeled directions for use. In 41 (82.0%) patients, prophylaxis of delayed bleeding was reported as an indication for endoscopic clipping. There were 3 instances of delayed bleeding. There were no device-related SAEs. The only technical difficulty was one instance of premature clip deployment. Conclusion: A novel TTSC with anchor prongs showed success in a range of defect closures, an acceptable safety profile, and low incidence of technical difficulties. (ClinicalTrials.gov number, NCT05653843)



Publication History

Received: 25 April 2024

Accepted after revision: 15 May 2024

Accepted Manuscript online:
21 May 2024

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany