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DOI: 10.1055/a-2330-8148
The Relationship Between Intramural Fat Accumulation and Sarcopenia on MR Enterography Exams in Patients with Crohn’s Disease
Der Zusammenhang zwischen intramuraler Fettansammlung und Sarkopenie bei MR-Enterografie-Untersuchungen bei Patienten mit Morbus Crohn
Abstract
Purpose
Research on magnetic resonance enterography (MRE) and sarcopenia for assessing Crohn’s disease (CD) is growing. Our study examined the connections between the presence of sarcopenia, intramural fat accumulation (IFA), and clinical, laboratory, and MRE findings.
Materials and Methods
This retrospective study was conducted on 112 patients with suspected or diagnosed CD who underwent 3-tesla MRE. The study examined the correlation between sarcopenia-related parameters and MRE findings. Results of MRE exams and clinical and laboratory results were statistically analyzed. The Kruskal-Wallis, Pearson chi-square, and Fisher-Freeman-Halton tests were used for comparison.
Results
It was determined that patients with active inflammation on a chronic basis had more IFA than the others (p<0.001). There were positive relationships between IFA and intramural edema (p<0.001). There were positive correlations between IFA and high b-values and negative correlations with apparent diffusion coefficient values (p<0.05). Positively significant relationships were found between IFA and wall thickness, affected segment length, disease duration, and sedimentation values (p<0.05). Strong correlations were found between sarcopenia and the CD activity index as well as wall thickness (p<0.001/p=0.003). There was no significant relationship between steroid usage and other variables.
Conclusion
The presence of IFA is associated with chronic inflammation. There was no clear relationship between steroid use and IFA. Our findings support the idea that sarcopenia is related to the activity of CD. Further comprehensive research is required on these subjects.
Key Points
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The usage of MR enterography for the management of CD is increasing day by day due to its advantages.
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There is a paucity of evidence regarding the relationship between sarcopenia and MR enterography findings in patients with CD.
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Intramural fat accumulation (IFA) is a sign of chronicity in patients with CD.
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The presence of IFA seems to be associated with active inflammation on a chronic basis.
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There was no clear relationship between steroid use and IFA.
Citation Format
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Algin O, Güneş YC, Cankurtaran RE et al. The Relationship Between Intramural Fat Accumulation and Sarcopenia on MR Enterography Exams in Patients with Crohn's Disease. Rofo 2025; DOI 10.1055/a-2330-8148
Zusammenfassung
Zweck
Die Forschung zur Magnetresonanz-Enterografie (MRE) und Sarkopenie nimmt bei der Beurteilung von Morbus Crohn (CD) zu. Unsere Studie untersuchte die Zusammenhänge zwischen dem Vorhandensein von Sarkopenie, intramuraler Fettansammlung (IFA) und klinischen, Labor- und MRE-Befunden.
Materialien und Methoden
Diese retrospektive Studie wurde an 112 Patienten mit vermuteter oder diagnostizierter Zöliakie durchgeführt, die sich einer 3-Tesla-MRE unterzogen. Die Studie untersuchte die Korrelation zwischen Sarkopenie-bezogenen Parametern und MRE-Befunden. Die Ergebnisse der klinischen und Labor-MRE-Untersuchungen wurden statistisch analysiert. Für Vergleiche wurden die Kruskal-Wallis-, Pearson-Chi-Quadrat- und Fisher-Freeman-Halton-Tests verwendet.
Ergebnisse
Es wurde festgestellt, dass Patienten mit aktiver Entzündung auf chronischer Basis mehr IFA hatten als die anderen (p<0,001). Es gab positive Beziehungen zwischen IFA und intramuralen Ödemen (p<0,001). Es gab positive Korrelationen von IFA mit hohen b-Werten und negative Korrelationen mit scheinbaren Diffusionskoeffizientenwerten (p<0,05). Es wurden positiv signifikante Beziehungen zwischen IFA und Wanddicke, der Länge des betroffenen Segments, der Krankheitsdauer oder den Sedimentationswerten gefunden (p<0,05). Es wurden starke Korrelationen zwischen Sarkopenie und dem CD-Aktivitätsindex sowie der Wanddicke gefunden (p<0,001/p=0,003). Es gab keinen signifikanten Zusammenhang zwischen der Verwendung von Steroiden und anderen Variablen.
Schlussfolgerung
Das Vorhandensein von IFA ist mit einer chronischen Entzündung verbunden. Es gab keinen klaren Zusammenhang zwischen Steroidkonsum und IFA. Unsere Ergebnisse stützen die Idee, dass Sarkopenie mit der Aktivität von CD zusammenhängt. Weitere umfassende Forschung zu diesen Themen ist erforderlich.
Kernaussagen
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Der Einsatz der MR-Enterographie bei der Behandlung von Morbus Crohn nimmt aufgrund ihrer Vorteile von Tag zu Tag zu.
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Es gibt nur wenige Belege für den Zusammenhang zwischen Sarkopenie und MR-Enterographie-Befunden bei Patienten mit Morbus Crohn.
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Intramurale Fettansammlung (IFA) ist ein Zeichen für Chronizität bei Patienten mit Morbus Crohn.
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Das Vorhandensein von IFA scheint mit einer aktiven, chronischen Entzündung verbunden zu sein.
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Es gab keinen eindeutigen Zusammenhang zwischen Steroidkonsum und IFA.
Publication History
Received: 26 January 2024
Accepted after revision: 12 May 2024
Article published online:
08 July 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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References
- 1 Evrimler S, Algin O. MR enterography with oral contrast agent composed of methylcellulose, low-dose barium sulfate, sorbitol, and lactulose: assessment of diagnostic performance, reliability, image quality, and patient tolerance. Clin Imaging 2016; 40 (03) 523-530
- 2 Bruining DH, Zimmermann EM, Loftus Jr EV. et al. Consensus recommendations for evaluation, interpretation, and utilization of computed tomography and magnetic resonance enterography in patients with small bowel Crohn’s disease. Gastroenterology 2018; 154 (04) 1172-1194
- 3 Cankurtaran RE, Gunes YC, Dirican E. et al. Sarcopenia and myosteatosis assessed by magnetic resonance enterography may predict negative outcomes in patients with Crohn’s disease. Turk J Gastroenterol 2023; 34 (08) 839-849
- 4 Alfarone L, Dal Buono A, Craviotto V. et al. Cross-Sectional Imaging Instead of Colonoscopy in Inflammatory Bowel Diseases: Lights and Shadows. J Clin Med 2022; 11 (02) 353
- 5 Spooren CEGM, Lodewick TM, Beelen EMJ. et al. The reproducibility of skeletal muscle signal intensity on routine magnetic resonance imaging in Crohn’s disease. J Gastroenterol Hepatol 2020; 35 (11) 1902-1908
- 6 Bugdaycı O, Eker N. The impact of sarcopenia and sarcopenic obesity on survival in children with Ewing sarcoma and osteosarcoma. Pediatr Radiol 2023; 53 (05) 854-861
- 7 Celentano V, Kamil-Mustafa L, Beable R. et al. Preoperative assessment of skeletal muscle mass during magnetic resonance enterography in patients with Crohn’s disease. Updates Surg 2021; 73 (04) 1419-1427
- 8 Cruz-Jentoft AJ, Bahat G, Bauer J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48 (01) 16-31
- 9 Atlan L, Cohen S, Shiran S. et al. Sarcopenia is a Predictor for Adverse Clinical Outcome in Pediatric Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr 2021; 72 (06) 883-888
- 10 Lee CH, Yoon H, Oh DJ. et al. The prevalence of sarcopenia and its effect on prognosis in patients with Crohn’s disease. Intest Res 2020; 18 (01) 79-84
- 11 Erol MY, Algin O. Detection of intramural fat accumulation by 3D-Dixon-Caipirinha-Vibe and this technique’s contribution to determining the chronicity of Chron’s disease. Magn Reson Imaging 2021; 85: 93-101
- 12 Best WR. Predicting the Crohn’s disease activity index from the Harvey-Bradshaw Index. Inflamm Bowel Dis 2006; 12 (04) 304-310
- 13 Nikodinovska V, Ivanoski S. Sarcopenia, more than just muscle atrophy: imaging methods for the assessment of muscle quantity and quality. Fortschr Röntgenstr 2023; 195 (09) 777-789
- 14 Kani HT, Tufan E. Are cross-sectional imaging modalities enough for sarcopenia assessment?. Turk J Gastroenterol 2024; 35 (01) 73-74
- 15 Mainenti PP, Castiglione F, Rispo A. et al. MR-enterography in Crohn’s disease: what MRE mural parameters are associated with one-year therapeutic management outcome?. Br J Radiol 2021; 94: 20200844
- 16 Cicero G, Alibrandi A, Blandino A. et al. DWI ratios: new indexes for Crohn’s disease activity at magnetic resonance enterography?. Radiol Med 2023; 128 (01) 16-26
- 17 Cansu A, Bekircavusoglu S, Oguz S. et al. Can diffusion-weighted imaging be used as an alternative to contrast-enhanced imaging on magnetic resonance enterography for the assessment of active inflammation in Crohn’s disease?. Medicine (Baltimore) 2020; 99 (08) e19202
- 18 Zoico E, Corzato F, Bambace C. et al. Myosteatosis and myofibrosis: relationship with aging, inflammation and insulin resistance. Arch Gerontol Geriatr 2013; 57 (03) 411-416