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Horm Metab Res
DOI: 10.1055/a-2294-6749
Original Article: Endocrine Care

Serum Uric Acid Combined with Homocysteine as a Predictive Biomarker of Lupus Nephritis

Juan Zhang
1   Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, Gansu, China
,
Jingjing Tian
1   Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, Gansu, China
,
Xiaoyuan Wang
1   Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, Gansu, China
,
Haili Shen
1   Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, Gansu, China
› Author Affiliations Funding Information Innovation Base and Talent Plan of Gansu Province — Grant number 21JR7RA437 Science and Technology Project of Gansu Province — Grant number 21JR1RA134 Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital (CY2021-MS-A18).
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Abstract

Serum uric acid (UA) and homocysteine (Hcy) are potential biomarkers of systemic lupus erythematosus (SLE). In this study, the expressions of UA and Hcy in SLE patients and the predictive value of these two parameters for lupus nephritis (LN) were studied. A total of 476 SLE patients were recruited to this case-control study, of which 176 SLE patients diagnosed with LN and 300 without LN. Serum UA and Hcy levels were analyzed. Multivariate logistic regression analysis was used to evaluate the relationship between serum UA and Hcy and LN. The receiver operating characteristic (ROC) curves were used to predict the role of combination of serum UA and Hcy in LN. We found that serum UA and Hcy levels in SLE patients with LN were significantly higher than those in controls (p<0.05). Multivariate logistic regressions showed that serum UA (OR+=+1.003, 95+% CI: 1.001–1.006, p+=+0.003), apolipoprotein B (Apo B) (OR+=+21.361, 95+% CI: 2.312–195.373, p+=+0.007) and Hcy (OR+=+1.042, 95+% CI: 1.011–1.080, p+=+0.014) were independent markers of LN. Combined serum UA and Hcy revealed a better result (AUC+=+0.718, 95+% CI: 0.670–0.676, p<0.001) in prediction of LN compared to that of the serum UA (AUC+=+0.710) and Hcy (AUC+=+0.657) independently. In conclusion, serum UA and Hcy could be predictive biomarkers of LN, and joint detection of serum UA and Hcy might be useful in the clinical setting.

Keywords

biomarkers - homocysteine - lupus nephritis - uric acid - systemic lupus erythematosus


Publication History

Received: 26 May 2023

Accepted after revision: 11 March 2024

Article published online:
06 May 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
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