Synthesis 2024; 56(11): 1793-1798
DOI: 10.1055/a-2261-3255
paper

Visible-Light-Driven Oxidative Chlorination of Alkyl sp3 C–H Bonds with HCl/Air at Room Temperature

Lai Xu
,
Chong Mei
,
Wenjun Lu


Abstract

An aerobic chlorination of alkyl sp3 C–H bonds of functionalized alkanes and simple alkanes has been established successfully under visible light at room temperature. The reaction is performed in the presence of catalytic NaNO2 using HCl or NaCl/acid as a chlorine source and air as a terminal oxidant under atmospheric pressure. It is suggested that NOCl from NaNO2/HCl is a crucial species in the catalytic cycle involving an aerobic oxidation and a photochemical radical chlorination.

Supporting Information



Publikationsverlauf

Eingereicht: 16. Dezember 2023

Angenommen nach Revision: 05. Februar 2024

Accepted Manuscript online:
05. Februar 2024

Artikel online veröffentlicht:
26. Februar 2024

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