Mitochondrien und Orthomolekularmedizin: neue Perspektiven in der Behandlung des Fibromyalgie-Syndroms

Zusammenfassung

Das Fibromyalgie-Syndrom, eine häufige Schmerzerkrankung mit Symptomen wie Schmerzen, Müdigkeit und kognitiven Störungen, ist eng mit mitochondrialen Dysfunktionen verbunden. Mitochondrien, die für die ATP-Produktion in den Zellen zuständig sind, spielen bei Fibromyalgie eine Schlüsselrolle. Dysfunktionale Mitochondrien führen zu verringerter ATP-Produktion und erhöhter Abhängigkeit vom weniger effizienten anaeroben Stoffwechsel, was die Symptome von Fibromyalgie verstärken kann. Aktuelle Forschungen zeigen eine deutliche Korrelation zwischen mitochondrialen Dysfunktionen und Fibromyalgie, einschließlich Störungen im Muskelenergiestoffwechsel und Anzeichen von oxidativem sowie nitrosativem Stress. Orthomolekularmedizinische Ansätze wie die Supplementierung mit Koenzym Q10, L-Carnitin, B-Vitaminen, D-Ribose und R-Alpha-Liponsäure könnten die mitochondriale Funktion verbessern und bieten neue Behandlungsmöglichkeiten. Diese Methoden zielen darauf ab, die zugrunde liegende Mitochondriopathie zu behandeln, und könnten einen wesentlichen Fortschritt in der Behandlung von Fibromyalgie darstellen. Zusätzlich spielen Lebensstil- und Verhaltensansätze eine wichtige Rolle in der Therapie, indem sie die mitochondriale Biogenese und den Muskelstoffwechsel fördern.

Abstract

The fibromyalgia syndrome, a common pain disorder with symptoms such as pain, fatigue, and cognitive disorders, is closely linked to mitochondrial dysfunctions. Mitochondria, which are responsible for the ATP production in the cells, play a significant role with fibromyalgia. Dysfunctional mitochondria lead to a decreased ATP production and an increased dependency on less efficient anaerobic metabolism, which can intensify the symptoms of fibromyalgia. Current research shows a clear correlation between mitochondrial dysfunctions and fibromyalgia, including disorders in the energy metabolism of the muscles and signs of oxidative as well as nitrosative stress. Approaches from orthomolecular medicine such as supplementation with coenzyme Q10, L-carnitine, B vitamins, D-ribose, and R-alpha lipoic acid could improve the mitochondrial function and offer new treatment options. These methods aim to treat the underlying mitochondriopathy and could mark a substantial progress in the treatment of fibromyalgia. Lifestyle and behavioral approaches also play a significant role in the therapy by stimulating mitochondrial biogenesis and muscle metabolism.

Schlüsselwörter

Fibromyalgie-Syndrom - Mitochondrien - Orthomolekulare Medizin - Mitochondriopathie - oxidativer Stress

Keywords

fibromyalgia syndrome - mitochondria - orthomolecular medicine - mitochondriopathy - oxidative stress

Publication History

Article published online:
09 April 2024

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