Horm Metab Res 2024; 56(04): 294-299
DOI: 10.1055/a-2256-6358
Original Article: Endocrine Care

Energy Metabolism in Residents in the Low- and Moderate Altitude Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus

1   Hospital Therapy, IK Akhunbaev Kyrgyz State Medical Academy Faculty of General Medicine, Bishkek, Kyrgyzstan
Matthias Breidert
2   Gastroenterology, Kantonsspital Olten, Olten, Switzerland
Judith Eschbach
3   Inoviem Scientific Research, Inoviem Scientific SAS, Illkirch, France
Indira Kudaibergenova
4   Kyrgyz State Medical Institute of Post-Graduate Training and Advanced Training named after S B Daniyarov, Bishkek, Kyrgyzstan
Uulkan Omurzakova
1   Hospital Therapy, IK Akhunbaev Kyrgyz State Medical Academy Faculty of General Medicine, Bishkek, Kyrgyzstan
Feruzakhan Uvaidillaeva
1   Hospital Therapy, IK Akhunbaev Kyrgyz State Medical Academy Faculty of General Medicine, Bishkek, Kyrgyzstan
Bermet Tagaeva
1   Hospital Therapy, IK Akhunbaev Kyrgyz State Medical Academy Faculty of General Medicine, Bishkek, Kyrgyzstan
Roza Sultanalieva
5   Therapy1, Kyrgyz-Russian Slavic University named after B N Yeltsin, Bishkek, Kyrgyzstan
Pierre Eftekhari
6   Inoviem, Inoviem Scientific, Strasbourg, France
› Author Affiliations


The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption in patients with MAFLD with and without DM2 living in the low- and moderate-altitude regions of Central Asia. Our study was carried out on patients living in low-altitude mountains: Bishkek, altitude=750–800 m; n=67 (MAFLD with DM 2: n=24; MAFLD without DM2: n=25; control: n=18), and At-Bashy District, Naryn Region, altitude=2046–2300 m; n=58 (MAFLD with DM2: n=28; MAFLD without DM2: n=18; control: n=12). Non-alcoholic fatty liver disease was diagnosed according to history, laboratory tests, liver ultrasound, and exclusion of other liver diseases. The level of liver fibrosis was determined using the FIB-4 score. Blood adenosine 5′-triphosphate (ATP) was determined using the CellTiter-Glo method. Healthy residents living in moderate altitudes have significantly higher levels of cytosolic ATP in their blood (p+≤+0.05) than residents living in low mountains. MAFLD is characterized by an increase in the level of ATP concentration in their blood. ATP concentration decreased significantly in patients with MAFLD with DM2 living in moderate-altitude in comparison to those living in low-altitude mountains. The results suggest that chronic altitude hypoxia leads to a breakdown in adaptive mechanisms of energy metabolism of ATP in patients with MAFLD with type 2 DM.

Publication History

Received: 01 October 2023

Accepted after revision: 28 January 2024

Article published online:
19 February 2024

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