Glucocorticoid-Induced Myopathy: Typology, Pathogenesis, Diagnosis,
                    and Treatment

Mengmeng Wu; Caixia Liu; Dong Sun

doi:10.1055/a-2246-2900

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2024; 56(05): 341-349
DOI: 10.1055/a-2246-2900

Review

Glucocorticoid-Induced Myopathy: Typology, Pathogenesis, Diagnosis, and Treatment

Autoren

Mengmeng Wu

¹Department of Nephrology, Xuzhou Medical University Affiliated Hospital, Xuzhou, China

²Graduate School, Xuzhou Medical University, Xuzhou, China
Caixia Liu

¹Department of Nephrology, Xuzhou Medical University Affiliated Hospital, Xuzhou, China
Dong Sun

¹Department of Nephrology, Xuzhou Medical University Affiliated Hospital, Xuzhou, China

³Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou, China

Abstract

Glucocorticoid-induced myopathy is a non-inflammatory toxic myopathy typified by proximal muscle weakness, muscle atrophy, fatigue, and easy fatigability. These vague symptoms coupled with underlying disorders may mask the signs of glucocorticoid-induced myopathy, leading to an underestimation of the disease’s impact. This review briefly summarizes the classification, pathogenesis, and treatment options for glucocorticoid-induced muscle wasting. Additionally, we discuss current diagnostic measures in clinical research and routine care used for diagnosing and monitoring glucocorticoid-induced myopathy, which includes gait speed tests, muscle strength tests, hematologic tests, bioelectrical impedance analysis (BIA), dual-energy X-ray absorptiometry (DXA), computed tomography (CT), magnetic resonance imaging (MRI), electromyography, quantitative muscle ultrasound, histological examination, and genetic analysis. Continuous monitoring of patients receiving glucocorticoid therapy plays an important role in enabling early detection of glucocorticoid-induced myopathy, allowing physicians to modify treatment plans before significant clinical weakness arises.

Keywords

glucocorticoids - glucocorticoid-induced myopathy - diagnostic measures - muscle

Volltext

Referenzen

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