Drug Res (Stuttg) 2024; 74(03): 123-132
DOI: 10.1055/a-2237-8566

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status

Saad Mohammed
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Tarique Mahmood
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Arshiya Shamim
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Farogh Ahsan
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Mohammad Shariq
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Saba Parveen
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Rufaida Waseem
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Aditya Singh
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
› Author Affiliations


Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2 diabetes. This study compiles exhaustively all accessible information on glipizide, from preclinical to clinical studies. Glipizide may be used in concert with TRAIL to treat cancer cells; in vitro studies have shown that it suppresses angiogenesis and vasculogenesis while shielding cells from glycation-induced damage. Anticonvulsant effects and modifications in the pharmacokinetics of other medications, such as Divalproex Sodium, were seen in glipizide in vivo experiments. Propranolol amplifies glipizide's hypoglycemic effect briefly in normal animals but consistently enhances it in diabetic ones. In the treatment of cancer and neurodegenerative poly(Q) illnesses, glipizide has demonstrated to offer potential therapeutic advantages. It is ineffective in preventing DENA-induced liver cancer and may cause DNA damage over time. The way glipizide interacts with genetic variants may increase the risk of hypoglycemia. Combining Syzygium cumini and ARBE to glipizide may enhance glycemic and lipid control in type 2 diabetes. Individuals with coronary artery disease who take glipizide or glyburide have an increased risk of death. The risk of muscular responses and acute pancreatitis is minimal when glipizide and dulaglutide are combined. In conclusion, glipizide has shown promising therapeutic efficacy across a variety of disorders.

Publication History

Received: 11 July 2023

Accepted: 01 January 2024

Article published online:
26 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag
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