Synthesis of Bioactive 1,2,3-Triazole-Fused Macrocycles via Azide-Alkyne Cycloaddition

Abstract

A systematic highlight of syntheses reported since 2006 of 1,2,3-triazole-fused macrocycles possessing biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory and antilarval action, is presented in this review. The well-renowned Cu-catalyzed azide-alkyne cycloaddition reaction was noted to be highly efficient and is one the most common methods utilized by scientists for the synthesis of 1,4-disubstituted triazole-fused macrocycles, whereas Ru-catalyzed cycloaddition is common for the formation of 1,5-disubstituted bioactive triazoles. This review would thus be extremely beneficial for both synthetic organic and medicinal chemists.

1 Introduction

2 Anticancer Derivatives

3 Antibacterial Derivatives

4 Derivatives with Dual Activity

5 Antilarval Derivatives

6 Anti-inflammatory Derivatives

7 Antiviral Derivatives

8 Anti-trypanosomal Derivatives

9 Derivatives with Miscellaneous Activities

10 Conclusion

Key words

triazole - macrocycles - anticancer - antibacterial - antiviral - bioactivity

Publication History

Received: 17 October 2023

Accepted after revision: 15 November 2023

Accepted Manuscript online:
16 November 2023

Article published online:
04 January 2024

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