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Klin Padiatr
DOI: 10.1055/a-2207-3153
Original Article

COVID-19 in Children with Chronic Kidney Disease; Does it Differ Much?

COVID-19 bei Kindern mit chronischer Nierenerkrankung; Gibt es große Unterschiede?
Demet Baltu 
1   Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
,
Eda Didem Kurt-Sukur
1   Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
,
Tugba Tastemel Ozturk
1   Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
,
Bora Gulhan
1   Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
,
Fatih Ozaltin
1   Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
,
Ali Duzova
1   Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
,
Rezan Topaloglu
1   Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
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Abstract

Background COVID-19 is known to have a mild course in children, however more data on pediatric chronic kidney disease (CKD) is needed. We aimed to assess the incidence and severity of COVID-19 in pediatric CKD patients.

Methods A questionnaire including demographics, COVID-19 history, symptoms, and vaccination status was applied to patients with CKD. We also retrospectively reviewed the presentation and outcomes of SARS-CoV-2 infection in this patient group from March 2020 to December 2021.

Results 220 patients were included, 48 were found to have experienced COVID-19. There was no significant difference regarding age, gender, underlying kidney disease, CKD stage, dialysis status, type or number of immunosuppressive medications, and glomerular filtration rate between patients with and without COVID-19. Most were infected by a household member (43.8%) and during outpatient or inpatient care (18.8%). Four (8.3%) were asymptomatic, and 43 (89.6%) had mild infection. Severe COVID-19 was observed in only one patient. Eleven (22.9%) patients with COVID-19 were previously vaccinated. Acute kidney injury was detected in 4 (8.3%); as stage 1 in all. Median follow-up after COVID-19 was 4.6 months. All patients fully recovered, and no renal disease flare or death was observed.

Conclusions Although the vaccination rate was low in our cohort, the majority of the children with COVID-19 showed a mild course. Along with the vaccination, general precautions seemed to be successful for this population.

Zusammenfassung

Hintergrund Es ist bekannt, dass COVID-19 in Kindern einen milden Verlauf hat, aber wenn es um pädiatrischen chronischen Nierenerkrankung (CNE) geht, es gibt wenig data. Unser Ziel war es, die Inzidenz und den Schweregrad von COVID-19 bei pädiatrischen CNE-Patienten zu beurteilen.

Methoden Ein Fragebogen, der Demografie, COVID-19-Anamnese, Symptome und Impfstatus umfasste, wurde bei Patienten mit chronischer Nierenerkrankung angewendet. Wir haben auch retrospektiv das Erscheinungsbild und die Ergebnisse einer SARS-CoV-2-Infektion in dieser Patientengruppe von März 2020 bis Dezember 2021 überprüft.

Ergebnisse 220 Patienten wurden eingeschlossen, bei 48 wurde festgestellt, dass sie an COVID-19 erkrankt waren. Es gab keinen signifikanten Unterschied hinsichtlich Alter, Geschlecht, zugrunde liegender Nierenerkrankung, CNE-Stadium, Dialysestatus, Art oder Anzahl der immunsuppressiven Medikamente und glomerulärer Filtrationsrate zwischen Patienten mit und ohne COVID-19. Die meisten wurden durch ein Haushaltsmitglied (43,8%) und während der ambulanten oder stationären Behandlung (18,8%) infiziert. Vier (8,3%) waren asymptomatisch, 43 (89,6%) hatten eine leichte Infektion. Nur bei einem Patienten wurde ein schwerer COVID-19-Verlauf beobachtet. Elf (22,9%) Patienten mit COVID-19 waren zuvor geimpft. Eine akute Nierenschädigung wurde bei 4 (8,3%) festgestellt; insgesamt als Stufe 1. Die mittlere Nachbeobachtungszeit nach COVID-19 betrug 4,6 Monate. Alle Patienten erholten sich vollständig, es wurde kein Aufflammen der Nierenerkrankung oder Tod beobachtet.

Schlussfolgerungen Obwohl die Impfrate in unserer Kohorte niedrig war, zeigte die Mehrheit der Kinder mit COVID-19 einen milden Verlauf. Neben der Impfung schienen auch allgemeine Vorsichtsmaßnahmen für diese Bevölkerungsgruppe erfolgreich zu sein.

Key words

COVID-19 - CKD - nephrotic syndrome - renal transplantation - immunosupression

Schlüsselwörter

COVID-19 - CNE - nephrotisches Syndrome - Nierentransplantation - Immunsuppression


Publication History

Article published online:
15 January 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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