CC BY-NC-ND 4.0 · J Neurol Surg Rep 2023; 84(04): e144-e145
DOI: 10.1055/a-2192-5775
Skull Base Oncology Case Series

Proton Therapy for Skull Base Chondrosarcoma

Dennis M. Tang
1   Department of Otolaryngology, Cedars-Sinai Medical Center, Los Angeles, California, United States
Raffaello M. Cutri
1   Department of Otolaryngology, Cedars-Sinai Medical Center, Los Angeles, California, United States
Arthur W. Wu
1   Department of Otolaryngology, Cedars-Sinai Medical Center, Los Angeles, California, United States
Chirag Patil
2   Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, United States
Zachary S. Zumsteg
3   Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California, United States
› Author Affiliations


Chondrosarcoma is a type of an endochondral bone malignancy that is primarily treated surgically with radiation therapy used in the adjuvant setting or in cases of unresectable disease. Proton therapy has potential advantages compared with traditional photon therapy for the treatment of tumors in close proximity to critical structures due to the theoretic lower exit dose. Studies have shown improved survival in patients with skull base chondrosarcoma who undergo proton therapy. However, there is a lack of randomized data. Further studies are needed to define the role of proton therapy in the treatment of skull base chondrosarcoma.

Publication History

Received: 27 September 2023

Accepted: 06 October 2023

Accepted Manuscript online:
16 October 2023

Article published online:
20 November 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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