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DOI: 10.1055/a-2189-7272
Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis
This research was supported by grants for the Development of Sustainable Application for Standard Herbal Resources from the Korea Institute of Oriental Medicine, Republic Korea (KSN1822320) and the Jeju Institute of Korean Medicine through the ‘Industrialization Utilization-Based Research Project of Jeju Dongjeong-gyul and Gwakhyang’ (ERT2011180).
Abstract
Agastache rugosa Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea. Thus, we aimed to reveal the morphological and micromorphological differences between A. rugosa grown on island and inland areas and their pharmacological effects on gastritis in an animal model by combining morphological and mass spectrophotometric analyses. Morphological analysis showed that island A. rugosa had slightly smaller plants and leaves than inland plants; however, the density of all types of trichomes on the leaves, petioles, and stems of island A. rugosa was significantly higher than that of inland plants. The essential oil component analysis revealed that pulegone levels were substantially higher in island A. rugosa than in inland A. rugosa. Despite the differences between island and inland A. rugosa, treatment with both island and inland A. rugosa reduced gastric damages by more than 40% compared to the gastritis induction group. In addition, expression of inflammatory protein was reduced by about 30% by treatment of island and inland A. rugosa. The present study demonstrates quantitative differences in morphology and volatile components between island and inland plants; significant differences were not observed between the gastritis-inhibitory effects of island and inland A. rugosa, and the efficacy of island A. rugosa was found to be similar to that of A. rugosa grown in inland areas.
Key words
Agastache rugosa - Lamiaceae - Agastachis Herba - scanning electron microscopy - pulegone - gastrointestinal diseases - gastric mucosal inflammationSupporting Information
- Ergänzendes Material
The whole membrane of the COX-2 and β-actin proteins expression (Fig. 1S) is in the Supporting Information. The results of the original GCMS chromatograms are presented in the Supporting Information (see Fig. 2S).
Publikationsverlauf
Eingereicht: 20. Februar 2023
Angenommen nach Revision: 28. September 2023
Artikel online veröffentlicht:
30. Oktober 2023
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