New Lupanes from Alstonia scholaris Reducing Uric Acid Level

Bin-Yuan Hu; Yun-Li Zhao; Yuan Xu; Xiao-Na Wang; Xiao-Dong Luo

doi:10.1055/a-2186-3260

Planta Medica, Inhaltsverzeichnis

Planta Med 2024; 90(01): 38-46
DOI: 10.1055/a-2186-3260

Biological and Pharmacological Activity

Original Papers

New Lupanes from Alstonia scholaris Reducing Uric Acid Level

Bin-Yuan Hu‡

¹Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China

,

Yun-Li Zhao‡

¹Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China

,

Yuan Xu

¹Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China

,

Xiao-Na Wang

¹Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China

,

Xiao-Dong Luo

¹Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China

²State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

› Institutsangaben

Abstract

Twelve lupanes including three new compounds named alstoscholarilups A−C (1–3) were isolated from the leaves of Alstonia scholaris. Their structures were elucidated by spectroscopic analysis and ECD calculation. Structurally, compound 1 with a rare A ring-seco skeleton formed lactone and degraded C-3, while 2 with a 28-nor and 3 with a 29-nor-lupane skeleton supported the phytochemical diversity and novelty of the plant. Pharmacologically, compounds 4, 7, and 10 reduced the serum uric acid (UA) levels of mice significantly.

Key words

Alstonia scholaris - Apocynaceae - reducing UA levels - lupanes

Volltext

Referenzen

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