Hamostaseologie 2024; 44(02): 143-149
DOI: 10.1055/a-2178-6508
Review Article

Cancer-Associated Venous Thromboembolism—Diagnostic and Therapeutic Considerations: An Update Based on the Revised AWMF S2k Guideline

Diagnostik und Therapie der Malignom-assoziierten venösen Thromboembolie
Hanno Riess
1   Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
Jan Beyer-Westendorf
2   Department of Hematology, Medical Faculty, University Hospital Carl Gustav-Carus, Dresden, Germany
Uwe Pelzer
1   Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
Robert Klamroth
3   Department of Internal Medicine and Vascular Medicine, Vivantes Hospital in Friedrichshain, Berlin, Germany
Birgit Linnemann
4   Cardiology III – Angiology, Department of Cardiology, University Hospital of the Johannes-Gutenberg University, Mainz, Germany
› Author Affiliations


Patients with cancer are prone to develop venous thromboembolism (VTE) with negative impact on quality of life, morbidity, and mortality. Treatment of established VTE is often complex in patients with cancer. Treatment of cancer-associated VTE (CAT) basically comprises initial and maintenance treatment, for 3 to 6 months, secondary preventions, and treatment in special situations. Therapeutic anticoagulation is the treatment of choice in CAT. In addition to the efficacy and safety of low-molecular-weight heparin (LMWH) that had been recommended for decades, direct oral anti-factor Xa inhibitors, a subgroup of direct oral anticoagulants (DOACs), demonstrated their advantages along with the accompanying concerns in several randomized controlled treatment trials of CAT. The latest guidelines, such as the German AWMF-S2k Guideline “Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism,” agree with each other on most aspects with respect to the treatment of CAT. Encompassing recent clinical studies, and meta-analyses, as well as the focus on some special management aspects of CAT, the objective of this review is to present a current overview and recommendations for the treatment of CAT.

Publication History

Received: 16 August 2023

Accepted: 19 September 2023

Article published online:
22 November 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
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