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Planta Med 2024; 90(02): 84-95
DOI: 10.1055/a-2176-5881
Biological and Pharmacological Activity
Original Papers

The Potential of Berberine to Target Telocytes in Rabbit Heart

Min Yang
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
,
Tong Yang
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
,
Lu Mei
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
,
Yingxing Zhang
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
,
Chunhua Liang
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
,
Xuebing Bai
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
,
Zhenwei Zhang
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
,
Yonghong Shi
2   Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
,
Qiusheng Chen
1   MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
› Author AffiliationsThis study was supported by grants from the National Natural Science Foundation of China (No. 31 872 433), the Fundamental Research Funds for the Central Universities of China (No. KYZ201927), and the Priority Academic Program Development of Jiangsu Higher Educations.
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Correction: The Potential of Berberine to Target Telocytes in Rabbit HeartPlanta Med eFirst
DOI: 10.1055/a-2198-5523

Abstract

A brand-new class of interstitial cells, called telocytes, has been detected in the heart. Telocytes can connect and transmit signals to almost all cardiomyocytes; this is highly interrelated with the occurrence and development of heart diseases. Modern studies have shown that berberine has a therapeutic effect on cardiovascular health. However, berberineʼs mechanism of action on the cardiovascular system through cardiac telocytes is unclear. Interestingly, 5 µm of berberine remarkably decreased the concentration of intracellular calcium and membrane depolarization in cultured telocytes, upregulated the expression of CX43 and β-catenin, and downregulated the expressions of TRPV4 and TRPV1. Here, telocytes were identified in the vascular adventitia and intima, endocardium, myocardium, adventitia, and heart valves. Moreover, telocytes were broadly dispersed around cardiac vessels and interacted directly through gap junctions and indirectly through extracellular vesicles. Together, cardiac telocytes interact with berberine and then deliver drug information to the heart. Telocytes may be an essential cellular target for drug therapy of the cardiovascular system.

Key words

cardiac telocytes - berberine - Ca²⁺ - CX43


Publication History

Received: 24 April 2023

Accepted after revision: 10 September 2023

Accepted Manuscript online:
15 September 2023

Article published online:
17 October 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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